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Context Info
Confidence 0.06
First Reported 1988
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.33
Pain Relevance 1.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
muscle 1
intestinal epithelium 1
synaptic vesicle 1
USHBP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Serotonin 1 100.00 Very High Very High Very High
agonist 1 99.38 Very High Very High Very High
addiction 1 94.96 High High
cINOD 1 91.76 High High
tetrodotoxin 8 90.04 High High
fluoxetine 1 89.76 High High
cerebral cortex 1 82.32 Quite High
sodium channel 5 75.00 Quite High
member 8 1 75.00 Quite High
monoamine 1 72.40 Quite High
Disease Link Frequency Relevance Heat
Hyperplasia 6 95.24 Very High Very High Very High
Colon Cancer 9 93.64 High High
INFLAMMATION 1 91.52 High High
Apoptosis 6 85.52 High High
Stress 1 56.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Treatment with several different cAMP agonists stimulated phosphorylation of CRE-binding protein (CREB) and activated expression of c-IAP2 in a CREB-dependent manner.
Gene_expression (expression) of CRE-binding protein associated with agonist
1) Confidence 0.06 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 15078890 Disease Relevance 0.81 Pain Relevance 0.14
Bullfrog muscle appears to be a good tissue source for the purification of this soluble saxitoxin-binding protein.
Gene_expression (source) of saxitoxin-binding protein in muscle
2) Confidence 0.01 Published 1988 Journal Mol. Pharmacol. Section Abstract Doc Link 2448601 Disease Relevance 0 Pain Relevance 0.65
Here, we explored the mechanism of dietary protection by hCa by analyzing the expression of genes involved in the regulation of Ca uptake/flux in the intestinal epithelium, including the Ca-sensing receptor, vitamin D receptor, Ca binding protein, and transient receptor potential cation channels, subfamily V, members 5 and 6 (TRPV5/6).
Spec (analyzing) Gene_expression (expression) of binding protein in intestinal epithelium
3) Confidence 0.01 Published 2010 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 20508153 Disease Relevance 0.52 Pain Relevance 0.07
The synaptic vesicle protein synaptophysin and a 45 kDa protein found specifically in serotonergic synaptic vesicles, serotonin-binding protein (SBP), were each enriched in IGC fractions from E15 to postnatal day 5; SBP immunoreactivity increased approximately 10-fold between E15 and E20.
Gene_expression (enriched) of serotonin-binding protein in synaptic vesicle associated with serotonin
4) Confidence 0.01 Published 1994 Journal J. Neurosci. Section Abstract Doc Link 7509861 Disease Relevance 0 Pain Relevance 0.24

General Comments

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