INT24182

Context Info Confidence 0.06 First Reported 1988 Last Reported 2010 Negated 0 Speculated 1 Reported most in Abstract Documents 4 Total Number 4 Disease Relevance 1.33 Pain Relevance 1.12

Anatomy Link Frequency muscle 1 intestinal epithelium 1 synaptic vesicle 1 USHBP1 (Homo sapiens)

Pain Link Frequency Relevance Heat Serotonin 1 100.00 agonist 1 99.38 addiction 1 94.96 cINOD 1 91.76 tetrodotoxin 8 90.04 fluoxetine 1 89.76 cerebral cortex 1 82.32 sodium channel 5 75.00 member 8 1 75.00 monoamine 1 72.40

Disease Link Frequency Relevance Heat Hyperplasia 6 95.24 Colon Cancer 9 93.64 INFLAMMATION 1 91.52 Apoptosis 6 85.52 Stress 1 56.88

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Treatment with several different cAMP agonists stimulated phosphorylation of CRE-binding protein (CREB) and activated expression of c-IAP2 in a CREB-dependent manner.

Gene_expression (expression) of CRE-binding protein associated with agonist

1) Confidence 0.06 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 15078890 Disease Relevance 0.81 Pain Relevance 0.14

Bullfrog muscle appears to be a good tissue source for the purification of this soluble saxitoxin-binding protein.

Gene_expression (source) of saxitoxin-binding protein in muscle

2) Confidence 0.01 Published 1988 Journal Mol. Pharmacol. Section Abstract Doc Link 2448601 Disease Relevance 0 Pain Relevance 0.65

Here, we explored the mechanism of dietary protection by hCa by analyzing the expression of genes involved in the regulation of Ca uptake/flux in the intestinal epithelium, including the Ca-sensing receptor, vitamin D receptor, Ca binding protein, and transient receptor potential cation channels, subfamily V, members 5 and 6 (TRPV5/6).

Spec (analyzing) Gene_expression (expression) of binding protein in intestinal epithelium

3) Confidence 0.01 Published 2010 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 20508153 Disease Relevance 0.52 Pain Relevance 0.07

The synaptic vesicle protein synaptophysin and a 45 kDa protein found specifically in serotonergic synaptic vesicles, serotonin-binding protein (SBP), were each enriched in IGC fractions from E15 to postnatal day 5; SBP immunoreactivity increased approximately 10-fold between E15 and E20.

Gene_expression (enriched) of serotonin-binding protein in synaptic vesicle associated with serotonin

4) Confidence 0.01 Published 1994 Journal J. Neurosci. Section Abstract Doc Link 7509861 Disease Relevance 0 Pain Relevance 0.24

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