INT241822

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Context Info
Confidence 0.01
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.73
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CD4) cell adhesion (CD4) nucleus (HIVEP1)
intracellular (HIVEP1) plasma membrane (CD4) DNA binding (HIVEP1)
Anatomy Link Frequency
helper T lymphocyte 1
T-lymphocytes 1
CD4 (Homo sapiens)
HIVEP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 6 91.12 High High
antagonist 6 82.44 Quite High
headache 15 5.00 Very Low Very Low Very Low
abdominal pain 7 5.00 Very Low Very Low Very Low
Bioavailability 5 5.00 Very Low Very Low Very Low
peripheral neuropathy 5 5.00 Very Low Very Low Very Low
depression 5 5.00 Very Low Very Low Very Low
corticosteroid 3 5.00 Very Low Very Low Very Low
Versed 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 211 100.00 Very High Very High Very High
Infection 63 100.00 Very High Very High Very High
Opportunistic Infections 2 94.20 High High
Sprains And Strains 9 77.60 Quite High
Syndrome 5 74.56 Quite High
Immunodeficiency 3 74.20 Quite High
Toxicity 23 30.72 Quite Low
Disease Progression 6 25.84 Quite Low
Exanthema 22 5.00 Very Low Very Low Very Low
Vomiting 18 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To move forward with the most potent DARPins, the second-series DARPins 55.2 and 57.2, which show strong binding to human CD4 and inhibition of HIV infection in vitro [8], were examined for macaque reactivity.
CD4 Binding (binding) of HIV associated with acquired immune deficiency syndrome or hiv infection and infection
1) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2929209 Disease Relevance 0.35 Pain Relevance 0
During acute HIV infection, the viral envelope glycoprotein gp 120 binds to the CD4 receptor on the mature human helper T lymphocyte (CD4 cell).
CD4 Binding (binds) of HIV in helper T lymphocyte associated with acquired immune deficiency syndrome or hiv infection and infection
2) Confidence 0.01 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2701488 Disease Relevance 1.54 Pain Relevance 0.09
HIV gp120 binds to the CD4 receptor on the surface of T-lymphocytes, and the cell surface proteins CCR5 or CXCR4 act as coreceptors for viral attachment (Chan and Kim 1998).
CD4 Binding (binds) of HIV in T-lymphocytes associated with acquired immune deficiency syndrome or hiv infection
3) Confidence 0.01 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504066 Disease Relevance 0.85 Pain Relevance 0.13

General Comments

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