INT241854

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Context Info
Confidence 0.57
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 10
Disease Relevance 8.58
Pain Relevance 1.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
red blood cells 1
prefrontal 1
hb (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 7 98.80 Very High Very High Very High
fibrosis 483 96.40 Very High Very High Very High
Inflammation 50 89.52 High High
anesthesia 15 70.08 Quite High
Bioavailability 1 59.84 Quite High
cytokine 9 47.80 Quite Low
Inflammatory stimuli 2 39.20 Quite Low
monoamine 13 37.72 Quite Low
withdrawal 2 27.28 Quite Low
depression 11 20.72 Low Low
Disease Link Frequency Relevance Heat
Targeted Disruption 111 98.82 Very High Very High Very High
Lymphatic System Cancer 23 97.64 Very High Very High Very High
Pulmonary Disease 448 96.72 Very High Very High Very High
Idiopathic Pulmonary Fibrosis 483 96.40 Very High Very High Very High
Disease 121 94.48 High High
INFLAMMATION 53 89.52 High High
Nicotine Addiction 64 89.32 High High
Increased Venous Pressure Under Development 14 89.08 High High
Malaria 45 89.04 High High
Ganglion Cysts 1 86.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this study, we generated conditional HB-EGF KO mice using a Cre/loxP system and were able to confirm the disruption of HB-EGF in the prefrontal cortex and hippocampus of KO mice.
Localization (disruption) of HB-EGF in prefrontal associated with targeted disruption and hippocampus
1) Confidence 0.57 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2759290 Disease Relevance 1.18 Pain Relevance 0.05
In a study of 349 myeloma and lymphoma patients, Österborg and colleagues (2002) confirmed a QoL gain in the ESA-treated patients and a correlation between Hb increase and QoL improvement.


Localization (increase) of Hb associated with lymphatic system cancer
2) Confidence 0.41 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504072 Disease Relevance 0.68 Pain Relevance 0
Our studies using Western blot and commercial antibodies indicate that Hb is secreted to these samples and is present mainly as the larger complexes containing both Hb?
Localization (secreted) of Hb
3) Confidence 0.32 Published 2010 Journal Respir Res Section Body Doc Link PMC2949726 Disease Relevance 0.93 Pain Relevance 0.20
The secretion of Hb?
Localization (secretion) of Hb
4) Confidence 0.32 Published 2010 Journal Respir Res Section Body Doc Link PMC2949726 Disease Relevance 0.94 Pain Relevance 0.25
In fact, several investigators have emphasized the importance of Hb?
Localization (importance) of Hb
5) Confidence 0.30 Published 2010 Journal Respir Res Section Body Doc Link PMC2949726 Disease Relevance 0.49 Pain Relevance 0.11
Interestingly the larger molecular masses of spot 1 (27 kDa) and 2 (26 kDa) indicated the presence of Hb?
Localization (presence) of Hb
6) Confidence 0.30 Published 2010 Journal Respir Res Section Body Doc Link PMC2949726 Disease Relevance 1.09 Pain Relevance 0.28
Western blot analyses confirmed the presence of the monomers and complexes of Hb?
Localization (presence) of Hb
7) Confidence 0.30 Published 2010 Journal Respir Res Section Body Doc Link PMC2949726 Disease Relevance 0.81 Pain Relevance 0.16
Our studies using Western blot and commercial antibodies indicate that Hb is secreted to these samples and is present mainly as the larger complexes containing both Hb?
Localization (secreted) of Hb
8) Confidence 0.30 Published 2010 Journal Respir Res Section Body Doc Link PMC2949726 Disease Relevance 0.93 Pain Relevance 0.20
Next, the positive area of Hb?
Localization (area) of Hb
9) Confidence 0.26 Published 2010 Journal Respir Res Section Body Doc Link PMC2949726 Disease Relevance 0.90 Pain Relevance 0.22
Nitric oxide binds avidly to haem iron, and haemoglobin (Hb) is released into the circulation when red blood cells (RBC) are disrupted during parasite schizogony.
Localization (released) of Hb in red blood cells
10) Confidence 0.21 Published 2010 Journal Malar J Section Body Doc Link PMC2858213 Disease Relevance 0.63 Pain Relevance 0.03

General Comments

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