INT241859

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Context Info
Confidence 0.02
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.22
Pain Relevance 0.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (SLC40A1) transmembrane transport (SLC40A1) cytoplasm (SLC40A1)
Anatomy Link Frequency
plasma 1
SLC40A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 8 99.32 Very High Very High Very High
cytokine 7 97.48 Very High Very High Very High
fibrosis 8 5.00 Very Low Very Low Very Low
palliative 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Parenteral administration 1 5.00 Very Low Very Low Very Low
visual analogue scale 1 5.00 Very Low Very Low Very Low
vincristine 1 5.00 Very Low Very Low Very Low
tolerance 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 8 99.32 Very High Very High Very High
Anaemia 114 95.92 Very High Very High Very High
Hypoxia 3 90.76 High High
Chronic Disease 5 73.20 Quite High
Cancer 67 70.92 Quite High
Aging 1 64.40 Quite High
Iron Overload 50 50.00 Quite Low
Lymphatic System Cancer 23 50.00 Quite Low
Feline Leukemia 1 22.96 Low Low
Thalassemia 36 10.56 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, acute and chronic inflammation increase hepcidin expression and ferroportin degradation [7].
Protein_catabolism (degradation) of ferroportin associated with inflammation
1) Confidence 0.02 Published 2010 Journal Advances in Hematology Section Body Doc Link PMC2872757 Disease Relevance 0.61 Pain Relevance 0.10
Inflammatory cytokines induce the expression of the most important iron distribution regulator hepcidin, which in turn down-regulates and increases degradation of ferroportin, the sole exporter of iron from within the cells to the plasma compartment (Roy and Andrews 2005; Nemeth and Ganz 2006).
Protein_catabolism (degradation) of ferroportin in plasma associated with inflammation and cytokine
2) Confidence 0.02 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504072 Disease Relevance 0.61 Pain Relevance 0.22

General Comments

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