INT241860

Context Info Confidence 0.55 First Reported 2008 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 4 Disease Relevance 4.00 Pain Relevance 0

signal transduction (EPO) extracellular space (EPO) aging (EPO) extracellular region (EPO)

Anatomy Link Frequency liver 4 EPO (Homo sapiens)

Pain Link Frequency Relevance Heat vincristine 2 45.32 cytokine 10 27.28 Inflammation 8 18.96 cva 12 5.00 palliative 8 5.00 headache 4 5.00 Central nervous system 2 5.00 depression 2 5.00 Angina 2 5.00 Pain 2 5.00

Disease Link Frequency Relevance Heat Hypoxia 12 99.98 Apoptosis 2 90.40 Anaemia 344 89.08 Cancer 244 88.80 Iron Overload 6 87.88 Viral Infection 2 85.92 Wound Healing 2 67.20 Lymphatic System Cancer 48 63.56 Immunotherapy Of Cancer 14 62.72 Head & Neck Cancer 10 49.68

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The homeostatic balance is upheld via a sensitive system where hypoxia induces transcription of erythropoietin (Epo), produced by the kidneys.

Positive_regulation (induces) of Transcription (transcription) of Epo associated with hypoxia

1) Confidence 0.55 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504072 Disease Relevance 1.06 Pain Relevance 0

Human EPO is an acidic glycoprotein hormone, predominantly produced in the kidney and, to a lesser extent, the liver.17,18 Intracellular hypoxia causes increased transcription of EPO in a HIF-2?

Positive_regulation (causes) of Transcription (transcription) of EPO in liver associated with hypoxia

2) Confidence 0.46 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2697520 Disease Relevance 0.94 Pain Relevance 0

Human EPO is an acidic glycoprotein hormone, predominantly produced in the kidney and, to a lesser extent, the liver.17,18 Intracellular hypoxia causes increased transcription of EPO in a HIF-2?

Positive_regulation (increased) of Transcription (transcription) of EPO in liver associated with hypoxia

3) Confidence 0.46 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2697520 Disease Relevance 0.94 Pain Relevance 0

The homeostatic balance is upheld via a sensitive system where hypoxia induces transcription of erythropoietin (Epo), produced by the kidneys.

Positive_regulation (induces) of Transcription (transcription) of erythropoietin associated with hypoxia

4) Confidence 0.40 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504072 Disease Relevance 1.06 Pain Relevance 0

General Comments

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