INT241860

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Context Info
Confidence 0.55
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 4.00
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (EPO) extracellular space (EPO) aging (EPO)
extracellular region (EPO)
Anatomy Link Frequency
liver 4
EPO (Homo sapiens)
Pain Link Frequency Relevance Heat
vincristine 2 45.32 Quite Low
cytokine 10 27.28 Quite Low
Inflammation 8 18.96 Low Low
cva 12 5.00 Very Low Very Low Very Low
palliative 8 5.00 Very Low Very Low Very Low
headache 4 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
depression 2 5.00 Very Low Very Low Very Low
Angina 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoxia 12 99.98 Very High Very High Very High
Apoptosis 2 90.40 High High
Anaemia 344 89.08 High High
Cancer 244 88.80 High High
Iron Overload 6 87.88 High High
Viral Infection 2 85.92 High High
Wound Healing 2 67.20 Quite High
Lymphatic System Cancer 48 63.56 Quite High
Immunotherapy Of Cancer 14 62.72 Quite High
Head & Neck Cancer 10 49.68 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The homeostatic balance is upheld via a sensitive system where hypoxia induces transcription of erythropoietin (Epo), produced by the kidneys.
Positive_regulation (induces) of Transcription (transcription) of Epo associated with hypoxia
1) Confidence 0.55 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504072 Disease Relevance 1.06 Pain Relevance 0
Human EPO is an acidic glycoprotein hormone, predominantly produced in the kidney and, to a lesser extent, the liver.17,18 Intracellular hypoxia causes increased transcription of EPO in a HIF-2?
Positive_regulation (causes) of Transcription (transcription) of EPO in liver associated with hypoxia
2) Confidence 0.46 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2697520 Disease Relevance 0.94 Pain Relevance 0
Human EPO is an acidic glycoprotein hormone, predominantly produced in the kidney and, to a lesser extent, the liver.17,18 Intracellular hypoxia causes increased transcription of EPO in a HIF-2?
Positive_regulation (increased) of Transcription (transcription) of EPO in liver associated with hypoxia
3) Confidence 0.46 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2697520 Disease Relevance 0.94 Pain Relevance 0
The homeostatic balance is upheld via a sensitive system where hypoxia induces transcription of erythropoietin (Epo), produced by the kidneys.
Positive_regulation (induces) of Transcription (transcription) of erythropoietin associated with hypoxia
4) Confidence 0.40 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504072 Disease Relevance 1.06 Pain Relevance 0

General Comments

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