INT241863

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Context Info
Confidence 0.28
First Reported 2008
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 3.86
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (SLC40A1) transmembrane transport (SLC40A1) cytoplasm (SLC40A1)
Anatomy Link Frequency
bone marrow 1
gut 1
SLC40A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 10 96.48 Very High Very High Very High
Inflammation 11 96.08 Very High Very High Very High
tolerance 1 50.72 Quite High
fibrosis 8 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
palliative 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Parenteral administration 1 5.00 Very Low Very Low Very Low
visual analogue scale 1 5.00 Very Low Very Low Very Low
cva 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Chronic Disease 5 99.72 Very High Very High Very High
Anaemia 152 98.88 Very High Very High Very High
INFLAMMATION 11 96.08 Very High Very High Very High
Hypoxia 6 95.24 Very High Very High Very High
Nutritional Deficiencies 1 87.28 High High
Parkinson's Disease 1 85.36 High High
Renal Disease 7 84.88 Quite High
Ataxia 24 84.48 Quite High
Sideroblastic Anemia 16 84.04 Quite High
Aging 1 82.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recently published data suggests that hepcidin binds to ferroportin (FPN1), a cellular iron exporter, resulting in internalisation and loss of function [19].
FPN1 Binding (binds) of
1) Confidence 0.28 Published 2008 Journal BMC Nephrol Section Body Doc Link PMC2519060 Disease Relevance 0.93 Pain Relevance 0.13
IRE, and FPN1b, which lacks a 5?
FPN1b Neg (lacks) Binding (lacks) of
2) Confidence 0.22 Published 2010 Journal Biochemistry Section Body Doc Link PMC2885827 Disease Relevance 1.03 Pain Relevance 0
Hepcidin acts by binding to the ferroportin transporter, triggering its internalization and degradation, thereby diminishing net circulating iron by reducing iron absorption in the gut and increasing iron sequestration in the RES.
ferroportin transporter Binding (binding) of in gut
3) Confidence 0.01 Published 2010 Journal Advances in Hematology Section Body Doc Link PMC2872757 Disease Relevance 0.50 Pain Relevance 0.06
Under other conditions, like in B12 deficiency anemia treatment, this is no problem, but in ACD the hepcidin–ferroportin interaction reduces the possibility for iron provision to the bone marrow.


ferroportin Binding (interaction) of in bone marrow associated with anaemia and chronic disease
4) Confidence 0.01 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504072 Disease Relevance 1.39 Pain Relevance 0.03

General Comments

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