INT241873

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Context Info
Confidence 0.03
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.44
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

GTPase activity (TUBB) cytoskeleton-dependent intracellular transport (TUBB) cytoplasm (TUBB)
cytosol (TUBB) mitosis (TUBB) structural molecule activity (TUBB)
TUBB (Homo sapiens)
Pain Link Frequency Relevance Heat
dexamethasone 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
methotrexate 1 5.00 Very Low Very Low Very Low
peripheral neuropathy 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
dysesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Breast Cancer 29 98.36 Very High Very High Very High
Toxicity 6 94.28 High High
Advanced Or Metastatic Breast Cancer 2 86.56 High High
Metastasis 2 74.80 Quite High
Disease 9 49.12 Quite Low
Death 1 42.00 Quite Low
Cancer 5 31.76 Quite Low
Recurrence 5 28.20 Quite Low
Neutropenia 18 16.32 Low Low
Vomiting 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Docetaxel acts by binding to the beta-tubulin subunit of the microtubules, which causes stabilization of tubulin polymerization, resulting in cell cycle arrest at G2/M phase and inhibition of mitosis (Eisenhauer and Vermorken 1998).
beta-tubulin Binding (binding) of
1) Confidence 0.03 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504077 Disease Relevance 0.44 Pain Relevance 0

General Comments

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