INT24196

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Context Info
Confidence 0.45
First Reported 1988
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 0.79
Pain Relevance 2.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Chrna7) plasma membrane (Chrna7) cytoplasm (Chrna7)
Chrna7 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
lidocaine 2 98.04 Very High Very High Very High
sodium channel 24 96.72 Very High Very High Very High
addiction 4 93.20 High High
Myofascial pain syndrome 1 91.28 High High
Migraine 1 90.24 High High
local anesthetic 6 85.68 High High
tetrodotoxin 10 81.52 Quite High
Clonidine 1 73.36 Quite High
noradrenaline 1 71.20 Quite High
Potency 1 38.72 Quite Low
Disease Link Frequency Relevance Heat
Cramps 1 94.24 High High
Focal Dystonia 1 93.44 High High
Myofascial Pain Syndromes 1 91.28 High High
Headache 1 90.24 High High
Eczema 1 89.84 High High
Skin Appendage Disease 1 88.80 High High
Rhinitis 1 88.20 High High
Paralysis 1 77.96 Quite High
Clostridium Infection 1 74.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Brevetoxins and alpha-scorpion toxins cause further allosteric enhancement of BTX-B binding.
Positive_regulation (cause) of BTX-B Binding (binding) of
1) Confidence 0.45 Published 1993 Journal J. Biol. Chem. Section Abstract Doc Link 8394327 Disease Relevance 0 Pain Relevance 0.24
The pyrethroids deltamethrin and bifenthrin and the nonpyrethroid insecticide 2,2-bis(p-chlorophenyl)trichloroethane can partially substitute for RU39568 in enhancing BTX-B binding, but other pyrethroids are inactive.
Positive_regulation (enhancing) of BTX-B Binding (binding) of
2) Confidence 0.40 Published 1993 Journal J. Biol. Chem. Section Abstract Doc Link 8394327 Disease Relevance 0 Pain Relevance 0.26
Repetitive depolarizations greatly facilitated the binding of BTX with NaIIA channels while the membrane was held at -100 mV.
Positive_regulation (facilitated) of BTX Binding (binding) of
3) Confidence 0.39 Published 1994 Journal Pflugers Arch. Section Abstract Doc Link 8072851 Disease Relevance 0 Pain Relevance 0.30
Brevetoxins and alpha-scorpion toxins cause further allosteric enhancement of BTX-B binding.
Positive_regulation (enhancement) of BTX-B Binding (binding) of
4) Confidence 0.30 Published 1993 Journal J. Biol. Chem. Section Abstract Doc Link 8394327 Disease Relevance 0 Pain Relevance 0.24
The expanding range of therapeutic applications for BTX make it necessary for primary care physicians to understand the biochemistry, preparation, indications, and interactions of BTX.
Positive_regulation (necessary) of BTX Binding (interactions) of
5) Confidence 0.26 Published 2006 Journal J Am Osteopath Assoc Section Abstract Doc Link 17122031 Disease Relevance 0.79 Pain Relevance 0.18
Specific [3H]BTX-B binding was temperature dependent with highest levels of specific [3H]BTX-B binding observed at 7 degrees C.
Positive_regulation (dependent) of BTX-B Binding (binding) of
6) Confidence 0.18 Published 1993 Journal Comp. Biochem. Physiol. C, Comp. Pharmacol. Toxicol. Section Abstract Doc Link 8103729 Disease Relevance 0 Pain Relevance 0.18
Specific [3H]BTX-B binding was temperature dependent with highest levels of specific [3H]BTX-B binding observed at 7 degrees C.
Positive_regulation (dependent) of BTX-B Binding (binding) of
7) Confidence 0.18 Published 1993 Journal Comp. Biochem. Physiol. C, Comp. Pharmacol. Toxicol. Section Abstract Doc Link 8103729 Disease Relevance 0 Pain Relevance 0.17
In a concentration-dependent manner, yohimbine increased the dissociation constant (Kd) of high-affinity [3H]BTX-B binding without changing the maximal binding capacity (Bmax).
Positive_regulation (increased) of BTX-B Binding (binding) of
8) Confidence 0.08 Published 1988 Journal Biochem. Pharmacol. Section Abstract Doc Link 2449217 Disease Relevance 0 Pain Relevance 0.55

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