INT24197

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Context Info
Confidence 0.11
First Reported 1988
Last Reported 1993
Negated 1
Speculated 0
Reported most in Abstract
Documents 2
Total Number 4
Disease Relevance 0
Pain Relevance 1.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Chrna7) plasma membrane (Chrna7) cytoplasm (Chrna7)
Anatomy Link Frequency
brain 6
Chrna7 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
noradrenaline 1 99.60 Very High Very High Very High
Clonidine 1 98.98 Very High Very High Very High
local anesthetic 7 92.12 High High
lidocaine 2 82.80 Quite High
sodium channel 12 75.00 Quite High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Whereas certain neurotoxins modified the specific binding of [3H]BTX-B in trout brain synaptoneurosomes in a predictable fashion, other compounds known to affect specific [3H]BTX-B binding in mammalian brain preparations had no effect on specific [3H]BTX-B binding in the trout.
Regulation (modified) of BTX-B Binding (binding) of in brain
1) Confidence 0.11 Published 1993 Journal Comp. Biochem. Physiol. C, Comp. Pharmacol. Toxicol. Section Abstract Doc Link 8103729 Disease Relevance 0 Pain Relevance 0.14
Whereas certain neurotoxins modified the specific binding of [3H]BTX-B in trout brain synaptoneurosomes in a predictable fashion, other compounds known to affect specific [3H]BTX-B binding in mammalian brain preparations had no effect on specific [3H]BTX-B binding in the trout.
Regulation (effect) of BTX-B Binding (binding) of in brain
2) Confidence 0.11 Published 1993 Journal Comp. Biochem. Physiol. C, Comp. Pharmacol. Toxicol. Section Abstract Doc Link 8103729 Disease Relevance 0 Pain Relevance 0.13
Whereas certain neurotoxins modified the specific binding of [3H]BTX-B in trout brain synaptoneurosomes in a predictable fashion, other compounds known to affect specific [3H]BTX-B binding in mammalian brain preparations had no effect on specific [3H]BTX-B binding in the trout.
Regulation (affect) of BTX-B Binding (binding) of in brain
3) Confidence 0.11 Published 1993 Journal Comp. Biochem. Physiol. C, Comp. Pharmacol. Toxicol. Section Abstract Doc Link 8103729 Disease Relevance 0 Pain Relevance 0.13
Alpha 2-adrenoceptors are apparently not involved because clonidine and alpha-methyl-noradrenaline had no appreciable effect on [3H]BTX-B binding and did not antagonize the inhibitory effect of yohimbine.
Neg (no) Regulation (effect) of BTX-B Binding (binding) of associated with noradrenaline and clonidine
4) Confidence 0.05 Published 1988 Journal Biochem. Pharmacol. Section Abstract Doc Link 2449217 Disease Relevance 0 Pain Relevance 0.74

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