INT242004

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Context Info
Confidence 0.36
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 12
Disease Relevance 2.66
Pain Relevance 0.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Tcf7) DNA binding (Tcf7)
Anatomy Link Frequency
lymphocyte 2
nucleus 1
T-cell 1
Tcf7 (Mus musculus)
Pain Link Frequency Relevance Heat
Crohn's disease 80 93.64 High High
antagonist 42 90.36 High High
fibrosis 1 82.04 Quite High
ischemia 2 80.24 Quite High
Nicotine 7 66.16 Quite High
cINOD 20 52.32 Quite High
metalloproteinase 10 42.72 Quite Low
Inflammation 12 21.84 Low Low
aspirin 63 5.00 Very Low Very Low Very Low
COX2 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Nicotine Addiction 98 94.56 High High
Disease 100 93.64 High High
Hyperplasia 9 90.80 High High
Familial Adenomatous Polyposis 10 89.56 High High
Cancer 178 88.48 High High
Apoptosis 48 86.48 High High
Fibrosis 1 82.04 Quite High
Cv Unclassified Under Development 2 80.24 Quite High
Mesothelioma 110 79.04 Quite High
Increased Venous Pressure Under Development 1 77.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
-catenin to escape ubiquination, and enter the nucleus where it can bind to T-cell factor/lymphoid-enhancer factor (Tcf/Lef) transcription factor proteins thereby activating transcription of downstream effectors [45].
Tcf Binding (bind) of in nucleus
1) Confidence 0.36 Published 2008 Journal J Carcinog Section Body Doc Link PMC2507706 Disease Relevance 0.46 Pain Relevance 0
-catenin accumulates in the cytoplasm and nucleus, where it interacts with coregulators of transcription including T cell factor/lymphocyte enhancer factor (Tcf/Lef) to form a ?
T cell factor Binding (factor) of in lymphocyte
2) Confidence 0.36 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2955614 Disease Relevance 0.34 Pain Relevance 0
-catenin/Tcf interactions [62].
Tcf Binding (interactions) of
3) Confidence 0.36 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2955614 Disease Relevance 0 Pain Relevance 0
-catenin/Tcf complex similarly increases ?
Tcf Binding (complex) of
4) Confidence 0.36 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2955614 Disease Relevance 0 Pain Relevance 0
-catenin/Tcf complex, which prevents ?
Tcf Binding (complex) of
5) Confidence 0.36 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2955614 Disease Relevance 0.06 Pain Relevance 0
-catenin accumulates in the cytoplasm and nucleus, where it interacts with coregulators of transcription including T cell factor/lymphocyte enhancer factor (Tcf/Lef) to form a ?
Tcf Binding (interacts) of in lymphocyte
6) Confidence 0.36 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2955614 Disease Relevance 0.34 Pain Relevance 0
-catenin/Tcf/Lef complex
Tcf Binding (complex) of
7) Confidence 0.36 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2955614 Disease Relevance 0 Pain Relevance 0
-catenin/Tcf complex [68], suggesting that c-Jun functions as an adaptor protein to mediate the association of Dsh with the ?
Tcf Binding (complex) of
8) Confidence 0.36 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2955614 Disease Relevance 0 Pain Relevance 0
Similarly, the E2F1 promoter was found to contain two putative Tcf-binding elements, and promoter activity is inhibited by overexpression of ?
Tcf Binding (binding) of
9) Confidence 0.36 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2955614 Disease Relevance 0 Pain Relevance 0
Others include small molecule inhibitors which can interfere the formation of the Tcf/?
Tcf Binding (formation) of
10) Confidence 0.36 Published 2010 Journal J Hematol Oncol Section Body Doc Link PMC2954871 Disease Relevance 0.33 Pain Relevance 0.15
RNF138, initially named NARF (NLK-associated RING finger protein) [33], has been shown to ubiquitinate TCF (T-cell factor)/LEF (lymphoid enhancer factor) proteins, which leads to their degradation and hence inhibits Wnt signalling [34].
T-cell factor Binding (leads) of in T-cell
11) Confidence 0.36 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2708910 Disease Relevance 1.06 Pain Relevance 0.34
-catenin/Tcf complex
Tcf Binding (complex) of
12) Confidence 0.36 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2955614 Disease Relevance 0.07 Pain Relevance 0

General Comments

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