INT242011

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Context Info
Confidence 0.73
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.49
Pain Relevance 0.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Cdkn2a) aging (Cdkn2a) DNA binding (Cdkn2a)
protein complex (Cdkn2a) cytoplasm (Cdkn2a) nucleolus (Cdkn2a)
Anatomy Link Frequency
blood vessel 1
interneurons 1
Cdkn2a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ischemia 8 98.34 Very High Very High Very High
adenocard 1 91.08 High High
parabrachial 1 90.56 High High
nMDA receptor 3 89.48 High High
Ventral tegmentum 1 88.40 High High
Glutamate 14 81.84 Quite High
Calcium channel 2 79.92 Quite High
gABA 5 75.44 Quite High
Dopamine 111 73.40 Quite High
antagonist 11 40.28 Quite Low
Disease Link Frequency Relevance Heat
Acute Renal Failure 16 100.00 Very High Very High Very High
Malignant Neoplastic Disease 42 98.80 Very High Very High Very High
Mesothelioma 220 98.40 Very High Very High Very High
Cv Unclassified Under Development 8 98.34 Very High Very High Very High
Aneurism 1 96.90 Very High Very High Very High
Obstructive Jaundice 1 96.46 Very High Very High Very High
Apoptosis 24 84.64 Quite High
Renal Failure 4 81.12 Quite High
Cancer 66 80.08 Quite High
Adhesions 3 69.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Homozygous deletion of p16/CDKN2A has been reported in >70% of malignant mesotheliomas, and has been associated with poor prognosis [30,31].
Localization (deletion) of CDKN2A associated with malignant neoplastic disease and mesothelioma
1) Confidence 0.73 Published 2008 Journal J Carcinog Section Body Doc Link PMC2507706 Disease Relevance 0.73 Pain Relevance 0
Homozygous deletion of p16/CDKN2A has been reported in >70% of malignant mesotheliomas, and has been associated with poor prognosis [30,31].
Localization (deletion) of p16 associated with malignant neoplastic disease and mesothelioma
2) Confidence 0.73 Published 2008 Journal J Carcinog Section Body Doc Link PMC2507706 Disease Relevance 0.73 Pain Relevance 0
Acute renal failure (ARF) is a common and dangerous complication of cardiac surgery, especially after surgery for cardiac coronary artery bypass graft (CABG),1 obstructive jaundice,2 and aortic aneurysm.3 ARF frequently arises because of decreased tissue perfusion, ischemia, adverse effects of free radicals,4 and blood vessel constriction stimulating the release of angiotensins such as endothelins.5 ARF following CABG has been found to increase mortality, morbidity, and intensive care unit (ICU) stay, with some patients requiring dialysis.6,7 To date, no effective prophylaxis has been found to prevent ARF.
Localization (release) of ARF in blood vessel associated with acute renal failure, ischemia, aneurism and obstructive jaundice
3) Confidence 0.30 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2697583 Disease Relevance 1.03 Pain Relevance 0.15
and inhibits acetylcholine release from striatal cholinergic interneurons

[54].

Localization (release) of inhibits in interneurons
4) Confidence 0.01 Published 2008 Journal Neural Plasticity Section Body Doc Link PMC2519792 Disease Relevance 0 Pain Relevance 0.39

General Comments

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