INT242015

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Context Info
Confidence 0.16
First Reported 2008
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 5.74
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Mdm2, Trp53) enzyme binding (Mdm2, Trp53) protein complex assembly (Mdm2, Trp53)
protein complex (Mdm2, Trp53) cytoplasm (Mdm2, Trp53) cytosol (Mdm2, Trp53)
Mdm2 (Mus musculus)
Trp53 (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 15 5.00 Very Low Very Low Very Low
ischemia 6 5.00 Very Low Very Low Very Low
palliative 3 5.00 Very Low Very Low Very Low
Hippocampus 3 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
COX2 1 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
Angina 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sarcoma 18 99.32 Very High Very High Very High
Apoptosis 90 97.96 Very High Very High Very High
Viral Infection 3 97.60 Very High Very High Very High
Cancer 276 94.32 High High
Breast Cancer 10 90.56 High High
Recurrence 20 89.76 High High
Aging 22 84.04 Quite High
Injury 4 83.96 Quite High
Glioma 135 81.84 Quite High
Liposarcoma 24 79.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The MDM4 and MDM2 proteins suppress p53's transcriptional activity and target p53 for proteasomal degradation, respectively [22].
MDM2 Binding (target) of p53
1) Confidence 0.16 Published 2011 Journal Journal of Oncology Section Body Doc Link PMC3010739 Disease Relevance 1.36 Pain Relevance 0
Nutlin-3 is a compound that disrupts the binding between MDM2 and p53 leading to activation and accumulation of free p53 [153].
MDM2 Binding (binding) of p53
2) Confidence 0.15 Published 2011 Journal Journal of Oncology Section Body Doc Link PMC3010739 Disease Relevance 1.29 Pain Relevance 0
Nutlin-3 is a compound that disrupts the binding between MDM2 and p53 leading to activation and accumulation of free p53 [153].
MDM2 Binding (binding) of p53
3) Confidence 0.15 Published 2011 Journal Journal of Oncology Section Body Doc Link PMC3010739 Disease Relevance 1.16 Pain Relevance 0
The product of MDM2 interacts with the p53 protein and inhibits its ability to regulate genetic expression as a transcription factor.
MDM2 Binding (interacts) of p53
4) Confidence 0.14 Published 2008 Journal Clinics Section Body Doc Link PMC2664204 Disease Relevance 1.12 Pain Relevance 0
This allows MDM2 to inhibit p53, which can no longer induce cell cycle arrest and apoptosis.
MDM2 Neg (inhibit) Binding (inhibit) of p53 associated with apoptosis
5) Confidence 0.00 Published 2008 Journal J Carcinog Section Body Doc Link PMC2507706 Disease Relevance 0.82 Pain Relevance 0

General Comments

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