INT242025

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Context Info
Confidence 0.18
First Reported 2008
Last Reported 2008
Negated 1
Speculated 4
Reported most in Body
Documents 7
Total Number 22
Disease Relevance 15.72
Pain Relevance 0.36

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mitochondrion (CHDH) extracellular space (CRP) extracellular region (CRP)
Anatomy Link Frequency
heart 2
plaque 1
CRP (Homo sapiens)
CHDH (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 18 86.92 High High
Angina 142 67.84 Quite High
ischemia 48 31.28 Quite Low
tolerance 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 2224 100.00 Very High Very High Very High
Coronary Artery Disease 96 100.00 Very High Very High Very High
Atherosclerosis 234 99.50 Very High Very High Very High
Rupture 28 98.94 Very High Very High Very High
Weight Loss 22 98.16 Very High Very High Very High
Disease 86 97.58 Very High Very High Very High
Weight Gain 6 95.96 Very High Very High Very High
Metabolic Syndrome 52 91.92 High High
INFLAMMATION 18 86.92 High High
Nicotine Addiction 110 85.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Lange et al. [24] suggest that CRP may affect plaque rupture rather than atherosclerosis in a study reporting an association of CRP genotype with incident CHD in a subgroup but no association with CIMT in the same subgroup or in the study population as a whole.
CRP Neg (no) Binding (association) of CHD in plaque associated with coronary artery disease, atherosclerosis and rupture
1) Confidence 0.18 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2507732 Disease Relevance 1.01 Pain Relevance 0
There was important heterogeneity between individual studies in the association of circulating CRP with CHD that was not explained by differences in the distribution of sex, age or the proportion of incident cases between studies.
CRP Binding (association) of CHD associated with cv unclassified under development
2) Confidence 0.17 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2507759 Disease Relevance 0.28 Pain Relevance 0
This SNP was chosen because it has been shown to be consistently related to CRP levels and is therefore a robust instrument for exploring the causal association of CRP levels with disease outcomes.[12], [20], [29]–[32] Furthermore, this is the SNP that was used in the recent Mendelian randomization study to examine CRP association with CHD,[12] and it was the one CRP SNP that had been typed in all of our new studies.
CRP Spec (examine) Binding (association) of CHD associated with cv unclassified under development and disease
3) Confidence 0.17 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2507759 Disease Relevance 0.78 Pain Relevance 0.05
However, the association between CRP genotype and CHD has not been confirmed by other studies or meta-analyses [19], [25], [27].
CRP Binding (association) of CHD associated with coronary artery disease
4) Confidence 0.15 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2507732 Disease Relevance 1.03 Pain Relevance 0
Association of CRP levels and CHD
CRP Binding (Association) of CHD associated with cv unclassified under development
5) Confidence 0.15 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2507759 Disease Relevance 0.92 Pain Relevance 0
Since our Mendelian randomization study relates the proportion of circulating CRP that is explained by rs1130864 to CHD risk, and there was no between study heterogeneity in the association of this genetic variant with CRP levels or with CHD, our Mendelian randomization results are unaffected by between study heterogeneity in the observational association of CRP with CHD.
CRP Binding (association) of CHD associated with cv unclassified under development
6) Confidence 0.15 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2507759 Disease Relevance 0.37 Pain Relevance 0
Table 4 shows the association between circulating CRP and CHD.
CRP Binding (association) of CHD associated with cv unclassified under development
7) Confidence 0.14 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2507759 Disease Relevance 0.96 Pain Relevance 0
However, we acknowledge that a very large genetic (Mendelian randomization) study is required to definitively demonstrate whether there is no causal association of CRP with CHD.
CRP Binding (association) of CHD associated with cv unclassified under development
8) Confidence 0.14 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2507759 Disease Relevance 0.92 Pain Relevance 0
In this study of 4,610 cases (the study with the largest numbers to date to examine the association of variation in CRP with CHD), we present evidence that higher circulating CRP level is unlikely to be an important causal risk factor for CHD.
CRP Spec (examine) Binding (association) of CHD associated with cv unclassified under development
9) Confidence 0.14 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2507759 Disease Relevance 0.59 Pain Relevance 0
However, a very large sample size (around 20,000 cases and controls), with comprehensive tag SNP typing, such as that being assembled by the CRP-CHD genetics collaboration (CCGC) [28], will be necessary to confirm or refute a causal association of CRP with risk of CHD events.
CRP Binding (association) of CHD associated with coronary artery disease
10) Confidence 0.14 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2507732 Disease Relevance 0.75 Pain Relevance 0
Several observational studies show high circulating CRP to be associated with increased risk of coronary heart disease (CHD) events [4]–[6] and increased carotid intima-media thickness (CIMT) [7]–[9], a subclinical marker of atherosclerosis [10], [11].
CRP Binding (associated) of CHD in heart associated with coronary artery disease and atherosclerosis
11) Confidence 0.13 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2507732 Disease Relevance 0.82 Pain Relevance 0.04
Furthermore, CRP genotypes that are associated with higher CRP were not associated with BMI, nor with a range of other established or novel risk factors for CHD [19], [20], [22].
CRP Binding (associated) of CHD associated with coronary artery disease
12) Confidence 0.13 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2507732 Disease Relevance 0.81 Pain Relevance 0.04
Several observational studies show high circulating CRP to be associated with increased risk of coronary heart disease (CHD) events [4]–[6] and increased carotid intima-media thickness (CIMT) [7]–[9], a subclinical marker of atherosclerosis [10], [11].
CRP Binding (associated) of CHD in heart associated with coronary artery disease and atherosclerosis
13) Confidence 0.13 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2507732 Disease Relevance 0.82 Pain Relevance 0.04
We estimated the association of CRP genetic variant +1444C>T (rs1130864) with CRP levels and with CHD in five studies and then pooled these analyses (N?
CRP Spec (analyses) Binding (association) of CHD associated with cv unclassified under development
14) Confidence 0.13 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2507759 Disease Relevance 0.69 Pain Relevance 0
This should not have biased our results, which are consistent with other studies showing that genetic variation in several SNPs in CRP are not associated with CHD in the way predicted by their association with CRP levels (see introduction and further discussion below).
CRP Binding (associated) of CHD associated with cv unclassified under development
15) Confidence 0.13 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2507759 Disease Relevance 0.52 Pain Relevance 0
untranslated region of CRP with CRP and CHD in these studies.
CRP Binding (region) of CHD associated with cv unclassified under development
16) Confidence 0.13 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2507759 Disease Relevance 0.95 Pain Relevance 0.18
This approach was used by Casas et al.[12] to assess the association between CRP level and CHD among 3155 European men (985 CHD cases).
CRP Binding (association) of CHD associated with cv unclassified under development
17) Confidence 0.13 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2507759 Disease Relevance 1.02 Pain Relevance 0
It has been suggested that the exploitation of the principles of Mendelian inheritance can be used to determine unconfounded and unbiased estimates of associations between non-genetic risk factors and disease outcomes,[8]–[10] and that this “Mendelian randomization” approach could provide useful insights into the nature of the association between CRP and CHD.[11] In this approach, the association of a genotype that influences the modifiable risk factor of interest (in this case CRP) with outcome (CHD) is explored.
CRP Binding (association) of CHD associated with cv unclassified under development and disease
18) Confidence 0.13 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2507759 Disease Relevance 1.08 Pain Relevance 0
Meta-analyses of prospective observational studies have demonstrated a positive association between circulating CRP and CHD risk.[35]–[37] However, it remains unclear whether this association is causal or explained by confounding factors or reverse causality, or even underestimated as a result of attenuation by errors.[7], [38] The best method to establish causality for this association would be by randomization to an intervention that altered CRP levels but did not affect any other cardiovascular risk factors.
CRP Binding (association) of CHD associated with cv unclassified under development
19) Confidence 0.13 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2507759 Disease Relevance 0.45 Pain Relevance 0
The use of genetic variants as instrumental variables to determine the causal association between circulating CRP and CHD provides an alternative to such a randomized controlled trial, with the advantage that this approach can be performed in existing datasets and may be more generalisable than a randomized controlled trial.[8], [9], [10] It has also been suggested that CRP genetic profiling might have clinical utility in predicting CHD risk.[20]
CRP Spec (determine) Binding (association) of CHD associated with cv unclassified under development
20) Confidence 0.13 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2507759 Disease Relevance 0.51 Pain Relevance 0

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