INT242032

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Context Info
Confidence 0.01
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 1.92
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CRP, RS1) extracellular region (CRP, RS1) cell adhesion (RS1)
CRP (Homo sapiens)
RS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Angina 28 5.00 Very Low Very Low Very Low
ischemia 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 556 99.28 Very High Very High Very High
Death 12 91.28 High High
Nicotine Addiction 20 87.44 High High
Obesity 16 54.36 Quite High
Disease 20 27.04 Quite Low
Myocardial Infarction 36 5.00 Very Low Very Low Very Low
Atherosclerosis 24 5.00 Very Low Very Low Very Low
Cv General 3 Under Development 20 5.00 Very Low Very Low Very Low
Stroke 12 5.00 Very Low Very Low Very Low
Angina 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, the association of rs1130864 with CRP concentration in our in-house studies and previous publications supports an additive (per T allele) genetic model.
CRP Binding (association) of rs1130864
1) Confidence 0.01 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2507759 Disease Relevance 0.18 Pain Relevance 0
Despite the robust associations of rs1130864 with circulating CRP this variant explained only a small proportion of its variation: within BWHHS (women only) it explained 0.8%; within Caerphilly (men only) 0.4%; within Speedwell (men only) 0.6%; within Whitehall II (73% men) 0.4% and within HIMS (men only) 0.7%.
CRP Binding (associations) of rs1130864
2) Confidence 0.01 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2507759 Disease Relevance 0.48 Pain Relevance 0
Genotype (rs1130864) was associated with circulating CRP in all cohorts (Table 1), with the pooled ratio of geometric means comparing individuals with the TT genotype to those with the CT/CC genotype being 1.21 (95%CI: 1.15, 1.28) (Figure 3).
CRP Binding (associated) of rs1130864
3) Confidence 0.01 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2507759 Disease Relevance 0.60 Pain Relevance 0
Genotype (rs1130864) was associated with circulating CRP; the pooled ratio of geometric means of CRP level among individuals with the TT genotype compared to those with the CT/CC genotype was 1.21 (95%CI: 1.15, 1.28) and the pooled ratio of geometric means of CRP level per additional T allele was 1.14 (95%CI: 1.11, 1.18), with no strong evidence in either analyses of between study heterogeneity (I2?
CRP Binding (associated) of rs1130864
4) Confidence 0.01 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2507759 Disease Relevance 0.66 Pain Relevance 0

General Comments

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