INT242035

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Context Info
Confidence 0.02
First Reported 2008
Last Reported 2010
Negated 0
Speculated 3
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 3.41
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (SNRNP70) mitochondrion (CHDH) mRNA processing (SNRNP70)
RNA binding (SNRNP70) nucleus (SNRNP70)
Anatomy Link Frequency
heart 1
SNRNP70 (Homo sapiens)
CHDH (Homo sapiens)
SNRNP70 - P12A (1)
Pain Link Frequency Relevance Heat
Angina 20 56.12 Quite High
ischemia 6 19.56 Low Low
alcohol 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 278 100.00 Very High Very High Very High
Coronary Artery Disease 105 100.00 Very High Very High Very High
Disease 13 98.86 Very High Very High Very High
Metabolic Syndrome 3 93.00 High High
Obesity 21 87.12 High High
Body Weight 1 85.64 High High
Diabetes Mellitus 9 74.52 Quite High
Metabolic Disorder 1 67.32 Quite High
Atherosclerotic Plaque 1 61.52 Quite High
Nicotine Addiction 19 59.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The assumptions underlying the Mendelian randomization approach is that the genetic variant is associated with the modifiable risk factor (circulating CRP levels in this example) and that it is not related to the outcome of interest (CHD) other than through its association with the modifiable risk factor (i.e. there are no confounding factors relating genotype to CHD and genotype is not related to CHD through other pathways).[8], [9], [10] The rs1130864 SNP has been consistently shown to be associated with circulating CRP levels in males and females of European origin,[12], [20], [29]–[31] a finding that we have replicated here.
rs1130864 SNP Spec (finding) Binding (association) of CHD associated with cv unclassified under development
1) Confidence 0.02 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2507759 Disease Relevance 0.68 Pain Relevance 0
This SNP was chosen because it has been shown to be consistently related to CRP levels and is therefore a robust instrument for exploring the causal association of CRP levels with disease outcomes.[12], [20], [29]–[32] Furthermore, this is the SNP that was used in the recent Mendelian randomization study to examine CRP association with CHD,[12] and it was the one CRP SNP that had been typed in all of our new studies.
SNP Spec (examine) Binding (association) of CHD associated with cv unclassified under development and disease
2) Confidence 0.02 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2507759 Disease Relevance 0.86 Pain Relevance 0.06
One promoter SNP rs2236659 was associated with susceptibility to CHD.
SNP rs2236659 Binding (associated) of CHD associated with coronary artery disease
3) Confidence 0.01 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2838785 Disease Relevance 0.71 Pain Relevance 0
Early studies analyzed the association between the PPARG Pro12Ala SNP and coronary heart disease (CHD) in cohorts from North America.
SNP (P12A) Spec (analyzed) Binding (association) of CHD in heart associated with coronary artery disease
4) Confidence 0.01 Published 2009 Journal PPAR Research Section Body Doc Link PMC2792957 Disease Relevance 1.16 Pain Relevance 0

General Comments

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