INT242037

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Context Info
Confidence 0.07
First Reported 2008
Last Reported 2010
Negated 0
Speculated 3
Reported most in Body
Documents 3
Total Number 6
Disease Relevance 4.62
Pain Relevance 0.19

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nucleoplasm (SNRNP70) extracellular space (CRP) extracellular region (CRP)
mRNA processing (SNRNP70) RNA binding (SNRNP70) nucleus (SNRNP70)
CRP (Homo sapiens)
SNRNP70 (Homo sapiens)
Pain Link Frequency Relevance Heat
Angina 36 56.12 Quite High
Inflammation 13 50.24 Quite High
ischemia 15 19.56 Low Low
aspirin 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 695 100.00 Very High Very High Very High
Cardiovascular Disease 21 100.00 Very High Very High Very High
Disease 26 98.86 Very High Very High Very High
Stroke 17 98.36 Very High Very High Very High
Calcification 12 92.00 High High
Myocardial Infarction 49 86.24 High High
Obesity 21 69.44 Quite High
Atherosclerosis 73 66.36 Quite High
Nicotine Addiction 28 62.24 Quite High
Cv General 3 Under Development 26 56.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The assumptions underlying the Mendelian randomization approach is that the genetic variant is associated with the modifiable risk factor (circulating CRP levels in this example) and that it is not related to the outcome of interest (CHD) other than through its association with the modifiable risk factor (i.e. there are no confounding factors relating genotype to CHD and genotype is not related to CHD through other pathways).[8], [9], [10] The rs1130864 SNP has been consistently shown to be associated with circulating CRP levels in males and females of European origin,[12], [20], [29]–[31] a finding that we have replicated here.
CRP Binding (associated) of rs1130864 SNP associated with cv unclassified under development
1) Confidence 0.07 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2507759 Disease Relevance 0.55 Pain Relevance 0
This SNP was chosen because it has been shown to be consistently related to CRP levels and is therefore a robust instrument for exploring the causal association of CRP levels with disease outcomes.[12], [20], [29]–[32] Furthermore, this is the SNP that was used in the recent Mendelian randomization study to examine CRP association with CHD,[12] and it was the one CRP SNP that had been typed in all of our new studies.
CRP Spec (examine) Binding (association) of SNP associated with cv unclassified under development and disease
2) Confidence 0.06 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2507759 Disease Relevance 0.79 Pain Relevance 0.05
This SNP was chosen because it has been shown to be consistently related to CRP levels and is therefore a robust instrument for exploring the causal association of CRP levels with disease outcomes.[12], [20], [29]–[32] Furthermore, this is the SNP that was used in the recent Mendelian randomization study to examine CRP association with CHD,[12] and it was the one CRP SNP that had been typed in all of our new studies.
CRP Spec (examine) Binding (association) of SNP associated with cv unclassified under development and disease
3) Confidence 0.06 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2507759 Disease Relevance 0.86 Pain Relevance 0.06
This SNP was chosen because it has been shown to be consistently related to CRP levels and is therefore a robust instrument for exploring the causal association of CRP levels with disease outcomes.[12], [20], [29]–[32] Furthermore, this is the SNP that was used in the recent Mendelian randomization study to examine CRP association with CHD,[12] and it was the one CRP SNP that had been typed in all of our new studies.
CRP Spec (examine) Binding (association) of SNP associated with cv unclassified under development and disease
4) Confidence 0.06 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2507759 Disease Relevance 0.86 Pain Relevance 0.06
Finally, Lange and colleagues found differential associations of 4 SNPs in CRP with cardiovascular disease events.[19] One SNP (1919A/T) was associated with non-fatal stroke and all cardiovascular disease mortality in white participants, but was not associated with other cardiovascular outcomes (including CHD and carotid intima media thickness) in whites or with any cardiovascular outcomes in Afro-American participants.[19] A second SNP (790A/T) was associated with acute myocardial infarction in Afro-American participants only.[19]
CRP Binding (associations) of SNP associated with stroke, cardiovascular disease, cv unclassified under development and myocardial infarction
5) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2507759 Disease Relevance 1.12 Pain Relevance 0
The ALOX12 SNP also was associated with CRP level (P = .036), but also significantly associated with ICAM-1 level (P = .032) in a recessive pattern [rs2271316 GG (295.7), GC (268.3), CC (266.0)].
CRP Binding (associated) of SNP
6) Confidence 0.01 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2878676 Disease Relevance 0.44 Pain Relevance 0.03

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