INT242065

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Context Info
Confidence 0.12
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.65
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Cflar)
Anatomy Link Frequency
nucleus 1
Cflar (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 1 99.98 Very High Very High Very High
diabetic neuropathy 2 66.48 Quite High
Inflammation 5 63.84 Quite High
Inflammatory response 6 37.00 Quite Low
chemokine 7 5.00 Very Low Very Low Very Low
ischemia 6 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
adenocard 2 5.00 Very Low Very Low Very Low
Glutamate 2 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 154 99.36 Very High Very High Very High
Infection 46 98.96 Very High Very High Very High
Apoptosis 71 98.84 Very High Very High Very High
Hematological Disease 4 95.80 Very High Very High Very High
Cancer 58 94.84 High High
Hepatocellular Cancer 78 93.84 High High
Injury 80 80.56 Quite High
Diabetic Neuropathy 2 66.48 Quite High
INFLAMMATION 11 63.84 Quite High
Targeted Disruption 8 63.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Up-regulation of FLIP, caspase-8 inhibitor, enhanced NF-?
Positive_regulation (regulation) of FLIP
1) Confidence 0.12 Published 2008 Journal Current Genomics Section Body Doc Link PMC2685644 Disease Relevance 0.90 Pain Relevance 0.09
The early activation of FLIP (within one hour of SV40 infection, long before the viral genome enters the nucleus and starts transcribing) suggests that it would also be induced by VLPs.
Positive_regulation (activation) of FLIP in nucleus associated with infection
2) Confidence 0.11 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2515219 Disease Relevance 0.45 Pain Relevance 0
Of note, FLIP activation by SV40 may be another anti-apoptotic renal protective mechanism, in addition to AKT activation and Hsp70 upregulation.
Positive_regulation (activation) of FLIP associated with apoptosis
3) Confidence 0.08 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2515219 Disease Relevance 0.46 Pain Relevance 0
Cytokine-induced antiapoptotic molecule (CIAPIN1), a recently reported antiapoptotic molecule which plays an essential role in mouse definitive hematopoiesis, is considered a downstream effecter of the receptor tyrosine kinaseĀ–Ras signaling pathway.
Positive_regulation (induced) of antiapoptotic molecule associated with hematological disease and cytokine
4) Confidence 0.02 Published 2008 Journal Carcinogenesis Section Abstract Doc Link PMC2516489 Disease Relevance 0.84 Pain Relevance 0.05

General Comments

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