INT24209

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Context Info
Confidence 0.57
First Reported 1987
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 37
Total Number 37
Disease Relevance 16.52
Pain Relevance 17.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ifng) extracellular region (Ifng)
Anatomy Link Frequency
liver 2
spleens 2
bile ducts 1
lymphocyte 1
brain 1
Ifng (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 116 100.00 Very High Very High Very High
cytokine 102 100.00 Very High Very High Very High
withdrawal 16 99.80 Very High Very High Very High
methadone 8 99.78 Very High Very High Very High
qutenza 2 99.78 Very High Very High Very High
primary afferent fibers 1 99.34 Very High Very High Very High
Inflammation 102 99.16 Very High Very High Very High
antagonist 21 98.88 Very High Very High Very High
opioid receptor 19 98.44 Very High Very High Very High
analgesia 1 98.38 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 12 100.00 Very High Very High Very High
Necrosis 10 100.00 Very High Very High Very High
Sprains And Strains 5 99.98 Very High Very High Very High
Targeted Disruption 21 99.64 Very High Very High Very High
Disease 96 99.60 Very High Very High Very High
Injury 35 99.32 Very High Very High Very High
Hepatocellular Cancer 4 99.28 Very High Very High Very High
Cerebral Malaria 54 99.20 Very High Very High Very High
INFLAMMATION 111 99.16 Very High Very High Very High
Infection 47 99.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We had previously shown that chronic morphine treatment in vivo and in vitro decreases IL-2 and IFNgamma (Th1) protein levels and increases IL-4 and IL-5 (Th2) protein levels in a time-dependent manner.
Negative_regulation (decreases) of IFNgamma associated with morphine
1) Confidence 0.57 Published 2004 Journal J. Neuroimmunol. Section Abstract Doc Link 14741432 Disease Relevance 0.10 Pain Relevance 0.53
It was determined that 24-h morphine withdrawal resulted in a decrease in IFN-gamma, the Th1 signature cytokine, whereas the Th2 cytokine, IL-4, was increased.
Negative_regulation (decrease) of IFN-gamma associated with withdrawal, cytokine and morphine
2) Confidence 0.57 Published 2005 Journal J. Immunol. Section Abstract Doc Link 16081842 Disease Relevance 0 Pain Relevance 1.39
The decreased hepatic injury in MIF-/- mice correlated with a reduction in mRNA levels of interferon-gamma and a significant increase in heat shock protein expression, but was unrelated to the APAP-protein adduct formation in the liver.
Negative_regulation (reduction) of interferon-gamma in liver associated with paracetamol, shock and injury
3) Confidence 0.57 Published 2002 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 12051698 Disease Relevance 0.95 Pain Relevance 0.46
Both dibutyryl cyclic AMP and forskolin treatment inhibited IFN-gamma promoter activity.
Negative_regulation (inhibited) of IFN-gamma
4) Confidence 0.52 Published 2003 Journal J. Biol. Chem. Section Abstract Doc Link 12842891 Disease Relevance 0.34 Pain Relevance 0.92
Morphine inhibited phosphorylation of ERK1/2 and p38 MAPK; in addition, morphine treatment in the presence of either ERK1/2 or p38 MAPK inhibitor (PD98059 or SB203580) resulted in an additive inhibition of IFN-gamma promoter activity.
Negative_regulation (inhibition) of IFN-gamma associated with morphine
5) Confidence 0.52 Published 2003 Journal J. Biol. Chem. Section Abstract Doc Link 12842891 Disease Relevance 0.35 Pain Relevance 1.18
Our results show that morphine inhibited anti-CD3/CD28-stimulated IFN-gamma promoter activity in a dose-dependent manner.
Negative_regulation (inhibited) of IFN-gamma associated with morphine
6) Confidence 0.52 Published 2003 Journal J. Biol. Chem. Section Abstract Doc Link 12842891 Disease Relevance 0.35 Pain Relevance 0.78
The treatment significantly decreased corneal IFN-gamma and IL-18 protein levels and corneal perforation resulted.
Negative_regulation (decreased) of IFN-gamma associated with corneal perforation
7) Confidence 0.50 Published 2005 Journal Eur. J. Immunol. Section Abstract Doc Link 15832292 Disease Relevance 0.65 Pain Relevance 0.48
Pretreatment with RU486 blocked morphine-induced increases in IFN-beta, and reversed the suppression of IFN-gamma.
Negative_regulation (suppression) of IFN-gamma associated with morphine
8) Confidence 0.47 Published 2005 Journal J. Neuroimmunol. Section Abstract Doc Link 15589048 Disease Relevance 0.25 Pain Relevance 0.45
In addition in this paper, we show that chronic morphine treatment resulted in a decrease in IFNgamma and IL-2 mRNA and an increase in IL-4 and IL-5 mRNA accumulation in murine splenocytes.
Negative_regulation (decrease) of IFNgamma associated with morphine
9) Confidence 0.41 Published 2004 Journal J. Neuroimmunol. Section Abstract Doc Link 14741432 Disease Relevance 0.09 Pain Relevance 0.67
CONCLUSIONS: The results demonstrate for the first time that a combination of viral infection and constitutive expression of IL-2, but not IFN-gamma or IL-4, can result in demyelination and visual impairment in the optic nerves of ocularly infected mice.


Negative_regulation (combination) of IFN-gamma in optic nerves
10) Confidence 0.41 Published 2009 Journal Invest. Ophthalmol. Vis. Sci. Section Body Doc Link 19234357 Disease Relevance 0.06 Pain Relevance 0
One day prior to sublethal infection, balb/c mice were treated intravenously with various therapeutic concentrations of ibuprofen alone or ibuprofen in combination with a suboptimal dosage of murine recombinant interferon gamma, a lymphokine produced by T-helper cells.
Negative_regulation (dosage) of interferon gamma in T-helper cells associated with infection
11) Confidence 0.41 Published 1995 Journal Arzneimittelforschung Section Abstract Doc Link 7893261 Disease Relevance 0.67 Pain Relevance 0.18
Spleen cells from mice undergoing withdrawal also had decreased splenic mRNA and/or protein levels of IL-1beta, IL-1Ra, TNF-alpha, IL-12, and IFN-gamma.
Negative_regulation (decreased) of IFN-gamma in Spleen associated with withdrawal
12) Confidence 0.40 Published 2003 Journal J. Neuroimmunol. Section Abstract Doc Link 14597094 Disease Relevance 0 Pain Relevance 0.50
To conclude suppression of IFN-gamma and increase in alpha-class GSTs expression may exert a protective role in acute hepatotoxicity of APAP and 5 kGy GIHA showed comparable protective effect to that of UIHA.
Negative_regulation (suppression) of IFN-gamma associated with paracetamol and hepatotoxicity
13) Confidence 0.39 Published 2008 Journal Chem. Biol. Interact. Section Abstract Doc Link 18237725 Disease Relevance 0.31 Pain Relevance 0.29
Overexpression of NF-kappaB p65 rescued the inhibitory effect of morphine on IFN-gamma promoter activity.
Negative_regulation (effect) of IFN-gamma associated with morphine
14) Confidence 0.38 Published 2003 Journal J. Biol. Chem. Section Abstract Doc Link 12842891 Disease Relevance 0.33 Pain Relevance 1.26
However, only when NFATc1 was co-overexpressed with c-fos was the inhibitory effect of morphine on IFN-gamma promoter counteracted.
Negative_regulation (effect) of IFN-gamma associated with morphine
15) Confidence 0.38 Published 2003 Journal J. Biol. Chem. Section Abstract Doc Link 12842891 Disease Relevance 0.22 Pain Relevance 1.21
After depletion, decreased corneal IFN-gamma mRNA and increased disease severity, bacterial load, and PMN infiltrate resulted.
Negative_regulation (decreased) of IFN-gamma mRNA associated with disease
16) Confidence 0.37 Published 2005 Journal Eur. J. Immunol. Section Abstract Doc Link 15832292 Disease Relevance 0.68 Pain Relevance 0.41
However, significant suppression of IFN-gamma and interleukin (IL)-12 production was observed in spleens from morphine-treated mice.
Negative_regulation (suppression) of IFN-gamma in spleens associated with morphine
17) Confidence 0.34 Published 2005 Journal J. Neuroimmunol. Section Abstract Doc Link 15589048 Disease Relevance 0.27 Pain Relevance 0.43
Morphine treatment in wild type splenocytes inhibited IFN gamma and stimulated IL-4 protein synthesis.
Negative_regulation (inhibited) of IFN gamma
18) Confidence 0.31 Published 2001 Journal Surgery Section Body Doc Link 11490364 Disease Relevance 0 Pain Relevance 0
The OVA challenge-induced IFN-gamma and ET-1 productions were inhibited in IL-18(-/-) immunized mice, as well as ET-1 production in IFN-gamma(-/-) immunized mice.
Negative_regulation (inhibited) of IFN-gamma
19) Confidence 0.30 Published 2007 Journal Brain Behav. Immun. Section Abstract Doc Link 17194566 Disease Relevance 0.27 Pain Relevance 0.39
It was noticed that PBQ-induced writhes were diminished in IFN-gamma(-/-) mice and by the treatment with bosentan (mixed endothelin ETA/ETB receptor antagonist), BQ 123 (cyclo[DTrp-DAsp-Pro-DVal-Leu], selective endothelin ETA receptor antagonist), BQ 788 (N-cys-2,6 dimethylpiperidinocarbonyl-l-methylleucyl-d-1-methoxycarboyl-d-norleucine, selective endothelin ETB receptor antagonist) or indomethacin (cycloxigenase inhibitor).
Negative_regulation (diminished) of IFN-gamma associated with antagonist
20) Confidence 0.27 Published 2008 Journal Eur. J. Pharmacol. Section Abstract Doc Link 18511039 Disease Relevance 0.32 Pain Relevance 0.37

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