INT242105

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Context Info
Confidence 0.49
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.93
Pain Relevance 1.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CFP) extracellular region (CFP)
Anatomy Link Frequency
external 2
CFP (Homo sapiens)
Pain Link Frequency Relevance Heat
Spontaneous pain 1 99.60 Very High Very High Very High
insula 15 98.68 Very High Very High Very High
Lasting pain 60 96.48 Very High Very High Very High
Spinal cord 4 91.12 High High
Thalamus 12 87.80 High High
Pain 134 87.04 High High
Anterior cingulate cortex 27 78.72 Quite High
backache 6 69.48 Quite High
depression 62 69.12 Quite High
imagery 59 60.84 Quite High
Disease Link Frequency Relevance Heat
Pain 192 99.60 Very High Very High Very High
Congenital Anomalies 4 95.32 Very High Very High Very High
Nociception 6 89.44 High High
Aggression 6 88.32 High High
Hallucination 3 74.40 Quite High
Urological Neuroanatomy 7 73.04 Quite High
Low Back Pain 7 69.48 Quite High
Depression 79 69.12 Quite High
Repression 40 62.88 Quite High
Post-traumatic Stress Disorder 2 61.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For our sample of healthy adults, one possible explanation for increased dmPFC activation when ignoring or attending to SBN compared to baseline is an increased awareness of external stimuli.
Positive_regulation (increased) of Positive_regulation (increased) of PFC in external
1) Confidence 0.49 Published 2010 Journal Frontiers in Human Neuroscience Section Body Doc Link PMC2999982 Disease Relevance 0.25 Pain Relevance 0
Impoverished vmPFC activation in anger patients suggests that recruitment of this region is necessary for suppression of aggressive affect.
Positive_regulation (necessary) of Positive_regulation (activation) of vmPFC
2) Confidence 0.32 Published 2008 Journal Ann Gen Psychiatry Section Body Doc Link PMC2515304 Disease Relevance 0.53 Pain Relevance 0.03
One recent study [93] has shown that chronic spontaneous pain is associated with increased activation of the mPFC, a region involved in detection of unfavorable outcomes and processing negative emotions and response conflict [98].
Positive_regulation (increased) of Positive_regulation (activation) of mPFC associated with pain and spontaneous pain
3) Confidence 0.26 Published 2009 Journal Mol Pain Section Body Doc Link PMC2702328 Disease Relevance 1.15 Pain Relevance 1.24
By contrast, older adults showed the opposite pattern, interpreted as indicating that higher PFC activation is necessary for older adults to maintain the same level of performance as young people.
Positive_regulation (necessary) of Positive_regulation (activation) of PFC
4) Confidence 0.16 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2999838 Disease Relevance 0 Pain Relevance 0
Enhanced vmPFC activation for females during OP condition suggests that the engagement of the “resonant” mechanism in the regret network is particularly strong in emphatic individuals; insular activation, on the other hand, appears to be not related to regret per se, rather it can be more generally associated with the processing of emotional empathic responses, as also shown in previous studies [5], [7], [17].
Positive_regulation (Enhanced) of Positive_regulation (activation) of vmPFC
5) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2756584 Disease Relevance 0 Pain Relevance 0.05

General Comments

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