INT242107

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Context Info
Confidence 0.38
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 2.82
Pain Relevance 2.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (SYNM) cytoplasm (SYNM)
Anatomy Link Frequency
cingulate cortex 1
cerebellum 1
SYNM (Homo sapiens)
Pain Link Frequency Relevance Heat
insula 14 100.00 Very High Very High Very High
reflex sympathetic dystrophy 1 99.78 Very High Very High Very High
midbrain 4 99.76 Very High Very High Very High
depression 285 99.52 Very High Very High Very High
Thalamus 29 99.50 Very High Very High Very High
Pain 137 94.80 High High
iatrogenic 5 93.48 High High
Lasting pain 60 91.72 High High
Dopamine 133 88.12 High High
Anterior cingulate 39 85.88 High High
Disease Link Frequency Relevance Heat
Complex Regional Pain Syndromes 11 99.78 Very High Very High Very High
Depression 366 99.52 Very High Very High Very High
Cognitive Disorder 81 97.00 Very High Very High Very High
Pain 189 94.80 High High
Repression 200 75.12 Quite High
Low Back Pain 7 73.44 Quite High
Nociception 6 71.68 Quite High
Unconsciousness 282 63.40 Quite High
Reprotox - General 3 115 57.48 Quite High
Disorder Of Lipid Metabolism 4 43.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Specifically, we hypothesized that BOLD signals would be positively correlated with DAT (the lower the DAT the lower the activation in task specific regions and the higher the deactivation in the DMN).
Positive_regulation (activation) of DMN
1) Confidence 0.38 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2699543 Disease Relevance 0 Pain Relevance 0.22
Integrating this hypothesis into a model of depression, we can postulate that activating Cg25 and the DMN controls the full expression of affective, mnemonic and motivational behaviours promulgated by visceromotor centres.
Positive_regulation (activating) of DMN associated with depression
2) Confidence 0.33 Published 2008 Journal Ann Gen Psychiatry Section Body Doc Link PMC2515304 Disease Relevance 0.16 Pain Relevance 0.22
For example, it is possible that activation of Cg25 supports activation of the DMN and deactivation of Cg25 supports deactivation of the DMN and activation of the ON.
Positive_regulation (activation) of DMN
3) Confidence 0.33 Published 2008 Journal Ann Gen Psychiatry Section Body Doc Link PMC2515304 Disease Relevance 0.53 Pain Relevance 0.12
Impassioned behaviours deemed dangerous to the ego in the context of its environment may be denied expression by activating Cg25 and the DMN.
Positive_regulation (activating) of DMN
4) Confidence 0.33 Published 2008 Journal Ann Gen Psychiatry Section Body Doc Link PMC2515304 Disease Relevance 0.16 Pain Relevance 0.23
Increased VA load (VA-load), produced higher activation in the thalamus and midbrain and higher deactivation in the DMN, the cingulate cortex (BAs 24 and 32), and left insula (Fig. 4; Table 2).
Positive_regulation (deactivation) of DMN in cingulate cortex associated with insula, midbrain and thalamus
5) Confidence 0.27 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2699543 Disease Relevance 0.08 Pain Relevance 0.30
For example, it is possible that activation of Cg25 supports activation of the DMN and deactivation of Cg25 supports deactivation of the DMN and activation of the ON.
Positive_regulation (deactivation) of DMN
6) Confidence 0.24 Published 2008 Journal Ann Gen Psychiatry Section Body Doc Link PMC2515304 Disease Relevance 0.48 Pain Relevance 0.12
A second study investigated RSNs in female patients with complex regional pain syndrome and found increased connectivity between nodes of the salience network, including the bilateral insula and temporal pole, the bilateral cerebellum, and the left sensory-motor cortex; no changes were found in the vision-related network or the DMN between patients and healthy controls [111].
Positive_regulation (increased) of DMN in cerebellum associated with complex regional pain syndromes, insula and reflex sympathetic dystrophy
7) Confidence 0.22 Published 2009 Journal Mol Pain Section Body Doc Link PMC2702328 Disease Relevance 0.87 Pain Relevance 1.03
We propose that activation in the ON and deactivation in the DMN correlates with the process of object cathexis.


Positive_regulation (activation) of DMN
8) Confidence 0.22 Published 2008 Journal Ann Gen Psychiatry Section Body Doc Link PMC2515304 Disease Relevance 0.55 Pain Relevance 0.14

General Comments

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