INT242134

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Context Info
Confidence 0.74
First Reported 2003
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 4.83
Pain Relevance 0.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

chromosome organization (Apc) plasma membrane (Apc) nucleus (Apc)
protein complex assembly (Apc) cytoplasm (Apc)
Anatomy Link Frequency
neurites 3
lymphoid tissue 1
Apc (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 79 99.84 Very High Very High Very High
Inflammation 114 99.66 Very High Very High Very High
Nicotine 12 90.32 High High
Central nervous system 42 85.36 High High
Demyelination 1 61.32 Quite High
agonist 45 54.64 Quite High
Spinal cord 2 45.92 Quite Low
Kinase C 52 5.00 Very Low Very Low Very Low
cINOD 27 5.00 Very Low Very Low Very Low
depression 24 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Familial Adenomatous Polyposis 80 100.00 Very High Very High Very High
INFLAMMATION 131 99.66 Very High Very High Very High
Infection 41 99.28 Very High Very High Very High
Polyps 13 99.24 Very High Very High Very High
Colon Cancer 59 98.36 Very High Very High Very High
Disease 313 96.08 Very High Very High Very High
Adenocarcinoma 4 90.32 High High
Multiple Sclerosis 52 89.28 High High
Apoptosis 67 88.68 High High
Fungal Infection 3 85.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Localization of the full length APC protein indicates that it is neither nuclear or membrane bound and that it appears in the non-soluble fraction of the cell.
Localization (Localization) of APC associated with familial adenomatous polyposis
1) Confidence 0.74 Published 2003 Journal Hered Cancer Clin Pract Section Body Doc Link PMC2840009 Disease Relevance 0.95 Pain Relevance 0
Release of TNF, a pro-inflammatory cytokine mainly secreted by activated APC, was also analyzed.
Localization (secreted) of APC associated with inflammation and cytokine
2) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3012729 Disease Relevance 0.72 Pain Relevance 0.41
These mice have a germ-line mutation of the APC gene resulting in deregulated ?
Localization (mutation) of APC gene
3) Confidence 0.29 Published 2010 Journal PPAR Research Section Body Doc Link PMC2796461 Disease Relevance 1.16 Pain Relevance 0
Wnt-7a is able to induce the re-localization of APC to membranes, clustering of APC in neurites, and co-clustering of APC with the presynaptic protein markers, including P-synapsin, SV2, and synaptotagmin.
Localization (localization) of APC in neurites
4) Confidence 0.20 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2515306 Disease Relevance 0.50 Pain Relevance 0.11
7-nAChR could be a target of the Wnt pathway by regulating the pre-synaptic localization of APC and ?
Localization (localization) of APC
5) Confidence 0.20 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2515306 Disease Relevance 0.12 Pain Relevance 0.11
Wnt-7a is able to induce the re-localization of APC to membranes, clustering of APC in neurites, and co-clustering of APC with the presynaptic protein markers, including P-synapsin, SV2, and synaptotagmin.
Localization (localization) of APC in neurites
6) Confidence 0.17 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2515306 Disease Relevance 0.50 Pain Relevance 0.11
Wnt-7a is able to induce the re-localization of APC to membranes, clustering of APC in neurites, and co-clustering of APC with the presynaptic protein markers, including P-synapsin, SV2, and synaptotagmin.
Localization (localization) of APC in neurites
7) Confidence 0.17 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2515306 Disease Relevance 0.50 Pain Relevance 0.11
The interaction of the DC and T-cell usually occurs within lymphoid tissue immediately after migration of the APC from the site of infection.
Localization (migration) of APC in lymphoid tissue associated with infection
8) Confidence 0.03 Published 2011 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2963117 Disease Relevance 0.38 Pain Relevance 0.04

General Comments

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