INT242137

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Context Info
Confidence 0.39
First Reported 2008
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 2.99
Pain Relevance 0.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Gsk3b) carbohydrate metabolic process (Gsk3b) protein complex (Gsk3b)
response to stress (Gsk3b) cytoplasm (Gsk3b) cytosol (Gsk3b)
Anatomy Link Frequency
nerve 2
Gsk3b (Mus musculus)
Pain Link Frequency Relevance Heat
Nerve growth factor 3 98.98 Very High Very High Very High
Hippocampus 41 98.76 Very High Very High Very High
tolerance 20 94.56 High High
adenocard 2 90.52 High High
depression 19 82.56 Quite High
positron emission tomography 8 73.52 Quite High
corticosteroid 15 66.68 Quite High
Serotonin 14 61.44 Quite High
cytokine 4 54.00 Quite High
Eae 28 51.48 Quite High
Disease Link Frequency Relevance Heat
Stress 41 99.32 Very High Very High Very High
Amyloid Plaque 22 97.20 Very High Very High Very High
Impaired Glucose Tolerance 15 95.20 Very High Very High Very High
Cognitive Disorder 132 93.60 High High
Neuroblastoma 8 91.88 High High
Disease 403 89.40 High High
Attention Deficit Hyperactivity Disorder 6 87.32 High High
Targeted Disruption 164 85.92 High High
Depression 19 82.56 Quite High
Alzheimer's Dementia 31 74.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is possible that inactivation of GSK-3?
Spec (possible) Negative_regulation (possible) of Spec (possible) Positive_regulation (inactivation) of GSK-3
1) Confidence 0.39 Published 2009 Journal Mol Brain Section Body Doc Link PMC2785804 Disease Relevance 0.41 Pain Relevance 0.30
Together, these data support the conclusion that the selective inactivation of GSK-3?
Negative_regulation (support) of Positive_regulation (inactivation) of GSK-3
2) Confidence 0.33 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3017066 Disease Relevance 0.37 Pain Relevance 0.09
Here we demonstrate that lithium by the inhibition of GSK-3 increases ?
Negative_regulation (inhibition) of Positive_regulation (increases) of GSK-3
3) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004858 Disease Relevance 0.34 Pain Relevance 0.05
Inactivation of GSK-3 increases ?
Negative_regulation (Inactivation) of Positive_regulation (increases) of GSK-3
4) Confidence 0.25 Published 2010 Journal Journal of Osteoporosis Section Body Doc Link PMC2951123 Disease Relevance 0 Pain Relevance 0.06
Among other actions, it reduces the production of free radicals and microglia activation, stimulates the synthesis and release of the nerve growth factor, facilitates APP non-amyloidogenic processing and decreases activated GSK-3?
Negative_regulation (decreases) of Positive_regulation (activated) of GSK-3 in nerve associated with nerve growth factor
5) Confidence 0.23 Published 2009 Journal The Open Neurology Journal Section Body Doc Link PMC2684708 Disease Relevance 0.40 Pain Relevance 0.16
reducing the activation of GSK-3?
Negative_regulation (reducing) of Positive_regulation (activation) of GSK-3
6) Confidence 0.21 Published 2011 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC3004402 Disease Relevance 0.39 Pain Relevance 0
Melatonin administration decreased oxidative stress and tau hyperphosphorylation and reversed GSK-3 activation showing thereby that it not only acts as an antioxidant but also interferes with the phosphorylation system, particularly stress kinases [91].
Negative_regulation (reversed) of Positive_regulation (activation) of GSK-3 associated with stress
7) Confidence 0.21 Published 2011 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC3004402 Disease Relevance 0.74 Pain Relevance 0
-catenin and inhibits the increase in GSK-3?
Negative_regulation (inhibits) of Positive_regulation (increase) of GSK-3
8) Confidence 0.06 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2515306 Disease Relevance 0.35 Pain Relevance 0.03

General Comments

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