INT242142

Context Info Confidence 0.65 First Reported 2008 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 4 Total Number 4 Disease Relevance 1.07 Pain Relevance 0.11

unfolded protein binding (Dnajc5) protein folding (Dnajc5) plasma membrane (Dnajc5)

Anatomy Link Frequency T cells 1 Dnajc5 (Mus musculus)

Pain Link Frequency Relevance Heat Central nervous system 14 79.32 Inflammation 12 72.40 agonist 18 37.76 cytokine 4 32.96 Eae 2 27.92 Hippocampus 14 27.68 Kinase C 26 5.00 withdrawal 13 5.00 depression 12 5.00 cINOD 8 5.00

Disease Link Frequency Relevance Heat Drug Induced Neurotoxicity 24 96.56 Lifespan 3 86.32 Disease 146 83.52 INFLAMMATION 14 72.40 Malaria 20 65.76 Immunization 18 60.40 Creutzfeldt Jakob Disease 12 49.96 Disease Progression 3 44.40 Alzheimer's Dementia 12 33.12 Toxicity 16 31.48

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Interestingly, the cSP peptide completely blocks A?

Gene_expression (peptide) of cSP

1) Confidence 0.65 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2515306 Disease Relevance 0.27 Pain Relevance 0.04

binding site in Fz is homologous to cSP and that this is a relevant target for A?

Gene_expression (homologous) of cSP

2) Confidence 0.65 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2515306 Disease Relevance 0.43 Pain Relevance 0.04

The changes in CSP expression are of particular interest, as it has been shown that deletion of the CSP gene in mice (CSP?

Gene_expression (expression) of CSP

3) Confidence 0.23 Published 2010 Journal ASN NEURO Section Body Doc Link PMC2954441 Disease Relevance 0.16 Pain Relevance 0

producing CSP specific CD4+ T cells [29], [30].

Gene_expression (producing) of CSP in T cells

4) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2749339 Disease Relevance 0.20 Pain Relevance 0.04

General Comments

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