INT242145

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Context Info
Confidence 0.17
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.99
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Sfrp1) intracellular (Sfrp1) cytoplasm (Sfrp1)
cytosol (Sfrp1) extracellular space (Sfrp1) extracellular region (Sfrp1)
Anatomy Link Frequency
photoreceptors 2
Sfrp1 (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 13 28.88 Quite Low
agonist 9 5.00 Very Low Very Low Very Low
Central nervous system 6 5.00 Very Low Very Low Very Low
depression 6 5.00 Very Low Very Low Very Low
cINOD 4 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
Nicotine 3 5.00 Very Low Very Low Very Low
Hippocampus 3 5.00 Very Low Very Low Very Low
Pyramidal cell 1 5.00 Very Low Very Low Very Low
nMDA receptor 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Retinal Degeneration 1 99.44 Very High Very High Very High
Retina Disease 1 98.24 Very High Very High Very High
Apoptosis 13 94.64 High High
Disease 61 93.68 High High
Amyloid Plaque 6 79.32 Quite High
Neurodegenerative Disease 10 71.56 Quite High
Cancer 2 59.80 Quite High
Carcinoma 1 45.76 Quite Low
Death 3 14.80 Low Low
Drug Induced Neurotoxicity 12 9.52 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increased expression of sFRP 1, 2, 3 and 5 has been reported in Inherited Retinal Degenerations such as Retinitis Pigmentosa, which is characterized by progressive loss of photoreceptors due to apoptosis [60,61]. sFRPs can regulate apoptosis in vitro, in fact, sFRP2 a member of the family of secreted Frizzled-related proteins [62], is also known as secreted apoptosis-related protein-1 (SARP-1) [63].
Regulation (reported) of Gene_expression (expression) of sFRP 1 in photoreceptors associated with retinal degeneration, apoptosis and retina disease
1) Confidence 0.17 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2515306 Disease Relevance 0.99 Pain Relevance 0

General Comments

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