INT242152

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Context Info
Confidence 0.57
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 5.22
Pain Relevance 0.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Wnt2) molecular_function (Wnt2) cell-cell signaling (Wnt2)
cytoplasm (Wnt2)
Anatomy Link Frequency
intestine 1
Wnt2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Potency 2 96.56 Very High Very High Very High
Kinase C 52 95.04 Very High Very High Very High
agonist 36 93.36 High High
antagonist 9 88.52 High High
Inflammation 17 82.44 Quite High
Hippocampus 12 79.76 Quite High
cINOD 18 77.36 Quite High
metalloproteinase 1 67.68 Quite High
Central nervous system 25 10.80 Low Low
depression 24 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Toxicity 28 98.92 Very High Very High Very High
Carcinoma 32 98.02 Very High Very High Very High
Targeted Disruption 33 94.96 High High
Adenoma 33 94.52 High High
Myocardial Infarction 69 92.04 High High
Familial Adenomatous Polyposis 58 91.44 High High
Amyloid Plaque 24 89.20 High High
Drug Induced Neurotoxicity 48 88.76 High High
Injury 11 87.76 High High
Adenocarcinoma 1 87.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
-catenin degradation and thus, activating the transcription of Wnt target genes such as engrailed and cyclin-D1.
Transcription (transcription) of Wnt
1) Confidence 0.57 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2515306 Disease Relevance 0.23 Pain Relevance 0.34
activity and (c) a decrease in Wnt target gene transcription.
Transcription (transcription) of Wnt
2) Confidence 0.57 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2515306 Disease Relevance 0.69 Pain Relevance 0.10
-catenin, as well as the transcription of Wnt target genes en-1 and cyclin-D1 [115].
Transcription (transcription) of Wnt
3) Confidence 0.50 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2515306 Disease Relevance 0.63 Pain Relevance 0.12
suggesting that the transcription of Wnt target genes may be involved in these events.
Transcription (transcription) of Wnt
4) Confidence 0.44 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2515306 Disease Relevance 0.37 Pain Relevance 0.04
In addition, it has been reported that glucocorticoid-induced transcription of Wnt occurs in the intestine of mice [1].
Transcription (transcription) of Wnt in intestine
5) Confidence 0.31 Published 2008 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2532488 Disease Relevance 0 Pain Relevance 0
There have also been recent studies that have suggested “crosstalk” between the Wnt signalling pathway and the TGF-?
Transcription (pathway) of Wnt
6) Confidence 0.14 Published 2008 Journal Current Genomics Section Body Doc Link PMC2674304 Disease Relevance 1.75 Pain Relevance 0
Since aberrant activation of Wnt canonical signaling pathway is diversely involved in pathogenesis of carcinomas, there has been great interest in developing therapeutics that circumvent it either by inhibiting Wnt mediated transcription or by inactivating the target genes.
Transcription (transcription) of Wnt associated with carcinoma
7) Confidence 0.08 Published 2010 Journal J Hematol Oncol Section Body Doc Link PMC2954871 Disease Relevance 1.10 Pain Relevance 0.23
-catenin signaling, including transcription of Wnt target genes, is present.
Transcription (transcription) of Wnt
8) Confidence 0.05 Published 2010 Journal Basic Res Cardiol Section Body Doc Link PMC2916122 Disease Relevance 0.46 Pain Relevance 0.05

General Comments

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