INT242153

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.49
First Reported 2008
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 19
Total Number 19
Disease Relevance 11.87
Pain Relevance 1.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Wnt2) molecular_function (Wnt2) cell-cell signaling (Wnt2)
cytoplasm (Wnt2)
Anatomy Link Frequency
neuronal 2
dentate gyrus 1
Wnt2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
spinal inflammation 26 99.48 Very High Very High Very High
antagonist 36 97.06 Very High Very High Very High
Osteoarthritis 3 94.40 High High
cytokine 14 92.76 High High
Kinase C 91 90.92 High High
Central nervous system 51 90.56 High High
fibrosis 112 90.24 High High
fluoxetine 66 90.08 High High
agonist 66 82.24 Quite High
Nicotine 21 81.44 Quite High
Disease Link Frequency Relevance Heat
Disease 511 99.76 Very High Very High Very High
Low Back Pain 29 99.48 Very High Very High Very High
Fungal Infection 4 99.26 Very High Very High Very High
Neurodegenerative Disease 99 98.96 Very High Very High Very High
Apoptosis 202 98.80 Very High Very High Very High
Myeloid Leukemia 24 98.64 Very High Very High Very High
Osteoporosis 51 98.56 Very High Very High Very High
Leukemia 19 97.84 Very High Very High Very High
Lymphatic System Cancer 30 97.32 Very High Very High Very High
Osteoarthritis 3 94.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
insults suggesting that a sustained loss of the Wnt signaling function may be involved in the A?
Negative_regulation (loss) of Wnt
1) Confidence 0.49 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2515306 Disease Relevance 0.70 Pain Relevance 0
At the beginning of this decade (Early in 2000), we found a relationship between a loss of the Wnt signaling pathway activity and AD.
Negative_regulation (loss) of Wnt associated with disease
2) Confidence 0.49 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2515306 Disease Relevance 0.44 Pain Relevance 0
Another mechanism for the inhibition of the Wnt signaling is by sFRPs, which are also capable to disrupt the Wnt network signaling.
Negative_regulation (inhibition) of Wnt
3) Confidence 0.35 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2515306 Disease Relevance 0.92 Pain Relevance 0
In fact, strong evidence suggests that a loss of Wnt function is implicated in the pathophysiology of neuronal degeneration of AD.
Negative_regulation (loss) of Wnt in neuronal associated with disease
4) Confidence 0.35 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2515306 Disease Relevance 0.69 Pain Relevance 0.09
The loss of Wnt signaling cannot be just attributed to a loss of function.
Negative_regulation (loss) of Wnt
5) Confidence 0.35 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2515306 Disease Relevance 0.28 Pain Relevance 0.29
binds to the extracellular cysteine-rich domain of the Frizzled receptor (Fz) inhibiting Wnt/?
Negative_regulation (inhibiting) of Wnt
6) Confidence 0.35 Published 2008 Journal Mol Neurodegener Section Abstract Doc Link PMC2515306 Disease Relevance 0.54 Pain Relevance 0.08
binding to Fz and prevents inhibition of the Wnt signaling cascade.
Negative_regulation (inhibition) of Wnt
7) Confidence 0.35 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2515306 Disease Relevance 0.34 Pain Relevance 0.04
Bone formation and remodeling are believed to be regulated by Wnt signaling, and the levels of Dickkopf-1 (DKK-1), a Wnt inhibitor, are low in AS patients.11,12) Wnt proteins, which are a family of 19 glycoproteins, have a major impact on osteoblastogenesis and bone growth in fetuses.
Negative_regulation (inhibitor) of Wnt associated with spinal inflammation
8) Confidence 0.28 Published 2010 Journal Clinics in Orthopedic Surgery Section Body Doc Link PMC2981776 Disease Relevance 0.88 Pain Relevance 0.27
In addition, DKK1, an inhibitor of Wnt, has been found to be important in osteoblastic cell growth and differentiation.
Negative_regulation (inhibitor) of Wnt associated with osteoporosis
9) Confidence 0.14 Published 2010 Journal Advances in Hematology Section Body Doc Link PMC2905716 Disease Relevance 0.94 Pain Relevance 0.05
Blockade of wnt signalling reduces the number of proliferating neuronal restricted precursors (NRPs) but had no effect on the general population of proliferating cells or glia production [39].
Negative_regulation (Blockade) of wnt in neuronal
10) Confidence 0.07 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2915993 Disease Relevance 0.08 Pain Relevance 0.08
However, increased Wnt3a may be an essential ingredient of the stimulatory process, since we never observed one without the other, and inhibition of Wnt signalling reduces adult neurogenesis in the dentate gyrus [3].
Negative_regulation (inhibition) of Wnt in dentate gyrus associated with neurodegenerative disease
11) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965105 Disease Relevance 0.26 Pain Relevance 0.16
Scientists have revealed that esearchethacrynic acid (EA) and the antifungal agent ciclopiroxolamine (cic) could inhibit Wnt/?
Negative_regulation (inhibit) of Wnt associated with fungal infection
12) Confidence 0.05 Published 2010 Journal J Hematol Oncol Section Body Doc Link PMC2954871 Disease Relevance 1.09 Pain Relevance 0
The Hedgehog (Hh) inhibitor, cyclopamine, and the Wnt inhibitor, quercetin, could suppress the growth of a number of leukemia and lymphoma cells[65].
Negative_regulation (inhibitor) of Wnt associated with leukemia and lymphatic system cancer
13) Confidence 0.05 Published 2010 Journal J Hematol Oncol Section Body Doc Link PMC2954871 Disease Relevance 1.23 Pain Relevance 0
In addition, small molecule inhibitors of Wnt signaling effectively induce apoptosis in AML cells.
Negative_regulation (inhibitors) of Wnt associated with myeloid leukemia and apoptosis
14) Confidence 0.05 Published 2010 Journal J Hematol Oncol Section Body Doc Link PMC2954871 Disease Relevance 1.31 Pain Relevance 0.09
B signaling), dnAKT (an inhibitor of AKT signaling) and dnTCF4 (an inhibitor of Wnt signaling).
Negative_regulation (inhibitor) of Wnt
15) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908545 Disease Relevance 0.86 Pain Relevance 0
Anti-Dkk1 AntibodyDickoppf1 (DKK1) is a naturally occurring Wnt pathway antagonist which works by preventing the interaction between two key Wnt pathway coreceptors, LRP5/6 and the frizzled Wnt pathway receptor, which results in inhibition of Wnt signal transduction and impaired bone formation [105].
Negative_regulation (inhibition) of Wnt associated with antagonist
16) Confidence 0.02 Published 2011 Journal Journal of Osteoporosis Section Body Doc Link PMC3010683 Disease Relevance 0.23 Pain Relevance 0.09
Secreted frizzled related proteins are similar to DKK1 and Sclerostin in that they also inhibit Wnt/?
Negative_regulation (inhibit) of Wnt
17) Confidence 0.01 Published 2010 Journal Journal of Osteoporosis Section Body Doc Link PMC2951123 Disease Relevance 0.56 Pain Relevance 0.05
Subsequent work showed that three members of this family (DKK1, DKK2, and DKK4) were inhibitors of the Wnt/?
Negative_regulation (inhibitors) of Wnt
18) Confidence 0.01 Published 2010 Journal Journal of Osteoporosis Section Body Doc Link PMC2951123 Disease Relevance 0.28 Pain Relevance 0.04
One group, the focus of this paper, is based on antagonizing the functions of putative inhibitors of Wnt signaling, Dickkopf-1 (DKK1), and Sclerostin (SOST).
Negative_regulation (inhibitors) of Wnt
19) Confidence 0.01 Published 2010 Journal Journal of Osteoporosis Section Abstract Doc Link PMC2951123 Disease Relevance 0.24 Pain Relevance 0.04

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox