INT242171

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Context Info
Confidence 0.96
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 0.91
Pain Relevance 1.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (JUP) cell morphogenesis (JUP) structural molecule activity (JUP)
plasma membrane (JUP) cytoskeleton (JUP) nucleus (JUP)
JUP (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 39 96.84 Very High Very High Very High
tetrodotoxin 22 96.00 Very High Very High Very High
Pyramidal cell 3 86.96 High High
Hippocampus 11 52.00 Quite High
Central nervous system 18 24.64 Low Low
depression 28 5.00 Very Low Very Low Very Low
agonist 27 5.00 Very Low Very Low Very Low
cINOD 12 5.00 Very Low Very Low Very Low
Inflammation 12 5.00 Very Low Very Low Very Low
Glutamate receptor 11 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Toxicity 21 92.88 High High
Drug Induced Neurotoxicity 36 90.56 High High
Adhesions 6 90.48 High High
Disease 185 84.00 Quite High
Apoptosis 39 70.64 Quite High
Neurodegenerative Disease 30 68.32 Quite High
Amyloid Plaque 20 47.96 Quite Low
Death 9 47.04 Quite Low
Targeted Disruption 21 41.92 Quite Low
Alzheimer's Dementia 19 37.48 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
-catenin degradation, these Wnt-3a effects are potentiated by over-expression of Fz1, but not Fz2, and are significantly reduced when Fz1 is knocked down by antisense oligonucleotides in PC12 cells [92].
Protein_catabolism (degradation) of catenin
1) Confidence 0.96 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2515306 Disease Relevance 0.25 Pain Relevance 0.03
-catenin degradation and thus, activating the transcription of Wnt target genes such as engrailed and cyclin-D1.
Protein_catabolism (degradation) of catenin
2) Confidence 0.96 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2515306 Disease Relevance 0.23 Pain Relevance 0.34
-catenin degradation, and a ?
Protein_catabolism (degradation) of catenin
3) Confidence 0.96 Published 2009 Journal Molecular & Cellular Proteomics : MCP Section Abstract Doc Link PMC2667352 Disease Relevance 0.09 Pain Relevance 0
-catenin labels it for ubiquitination and rapid proteasomal degradation.
Protein_catabolism (degradation) of catenin
4) Confidence 0.64 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2515306 Disease Relevance 0.34 Pain Relevance 0.04
-catenin is degraded by the proteasome upon phosphorylation.
Protein_catabolism (degraded) of catenin
5) Confidence 0.64 Published 2009 Journal Molecular & Cellular Proteomics : MCP Section Body Doc Link PMC2667352 Disease Relevance 0 Pain Relevance 0.60

General Comments

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