INT242172

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Context Info
Confidence 0.64
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.06
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (LRP5) plasma membrane (LRP5)
Anatomy Link Frequency
adult brain 1
LRP5 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 1 76.24 Quite High
Kinase C 13 5.00 Very Low Very Low Very Low
agonist 9 5.00 Very Low Very Low Very Low
Central nervous system 6 5.00 Very Low Very Low Very Low
depression 6 5.00 Very Low Very Low Very Low
cINOD 4 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
Nicotine 3 5.00 Very Low Very Low Very Low
Hippocampus 3 5.00 Very Low Very Low Very Low
Pyramidal cell 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Familial Adenomatous Polyposis 1 55.76 Quite High
Disease 61 12.20 Low Low
Neurodegenerative Disease 10 6.28 Low Low
Apoptosis 13 5.00 Very Low Very Low Very Low
Drug Induced Neurotoxicity 12 5.00 Very Low Very Low Very Low
Toxicity 7 5.00 Very Low Very Low Very Low
Targeted Disruption 7 5.00 Very Low Very Low Very Low
Depression 6 5.00 Very Low Very Low Very Low
Amyloid Plaque 6 5.00 Very Low Very Low Very Low
Alzheimer's Dementia 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Dkk-1 is expressed at very low levels in the adult brain [11], and binds to LRP 5/6 and the transmembrane protein Kremen-2, promoting the endocytosis and subsequent degradation of LRP 5/6, which is no longer available as a co-receptor for Wnt [12].
Protein_catabolism (degradation) of LRP 5 in adult brain
1) Confidence 0.64 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2515306 Disease Relevance 0.06 Pain Relevance 0.04

General Comments

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