INT242173

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Context Info
Confidence 0.49
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.37
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (JUP) cell morphogenesis (JUP) structural molecule activity (JUP)
plasma membrane (JUP) cytoskeleton (JUP) nucleus (JUP)
JUP (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 9 92.32 High High
Nicotine 3 91.52 High High
Kinase C 13 5.00 Very Low Very Low Very Low
Central nervous system 6 5.00 Very Low Very Low Very Low
depression 6 5.00 Very Low Very Low Very Low
cINOD 4 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
Hippocampus 3 5.00 Very Low Very Low Very Low
Opioid 2 5.00 Very Low Very Low Very Low
nMDA receptor 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 45 98.40 Very High Very High Very High
Neuroblastoma 50 98.24 Very High Very High Very High
Pheochromocytoma 33 90.04 High High
Drug Induced Neurotoxicity 12 89.48 High High
Alzheimer's Dementia 5 88.00 High High
Disease 61 86.32 High High
Neurodegenerative Disease 10 85.04 High High
Apoptosis 14 82.56 Quite High
Glioma 2 72.80 Quite High
Medulloblastoma 1 60.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
-catenin signaling, including the activation of M1 muscarinic receptor and PKC, the use of Ibuprofen-ChE bi-functional compounds, PPAR ?
Positive_regulation (activation) of Gene_expression (signaling) of catenin
1) Confidence 0.49 Published 2008 Journal Mol Neurodegener Section Abstract Doc Link PMC2515306 Disease Relevance 0.52 Pain Relevance 0.09
Although Amitay et al. (2001) reported reduced expression of CTNNG in 9/20 neuroblastoma tumours, we observed promoter methylation in only 11% of neuroblastoma tumours and did not detect promoter methylation in the cell lines that demonstrated an increase expression of CTNNG after 5-aza-dC treatment.
Positive_regulation (increase) of Gene_expression (expression) of CTNNG associated with neuroblastoma and cancer
2) Confidence 0.40 Published 2008 Journal Endocrine-Related Cancer Section Body Doc Link PMC2519165 Disease Relevance 1.85 Pain Relevance 0

General Comments

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