INT242222

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Context Info
Confidence 0.35
First Reported 2008
Last Reported 2009
Negated 0
Speculated 2
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.77
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (AGTR1) signal transducer activity (AGTR1)
AGTR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 3 78.88 Quite High
Inflammation 31 65.36 Quite High
cytokine 5 5.00 Very Low Very Low Very Low
Angina 3 5.00 Very Low Very Low Very Low
Analgesic 2 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
adenocard 1 5.00 Very Low Very Low Very Low
Inflammatory stimuli 1 5.00 Very Low Very Low Very Low
Kinase C 1 5.00 Very Low Very Low Very Low
Potency 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Renal Disease 20 93.64 High High
Atherosclerosis 35 93.28 High High
Hypertension 17 91.12 High High
Chronic Renal Failure 10 87.36 High High
Coronary Artery Disease 11 87.12 High High
Diabetes Mellitus 8 82.16 Quite High
Pathologic Processes 1 79.08 Quite High
Disorder Of Lipid Metabolism 18 66.64 Quite High
INFLAMMATION 34 65.36 Quite High
Acute Coronary Syndrome 9 62.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
While speculative, it is intriguing to consider the possibility that more directed pharmacologic therapy might derive from findings like these; for example, blockade of the AT1R with angiotensin receptor blockade might be especially beneficial in these patients [17].
Spec (might) Positive_regulation (beneficial) of Negative_regulation (blockade) of AT1R
1) Confidence 0.35 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2650781 Disease Relevance 1.01 Pain Relevance 0
All these findings suggest a possible role for AT1-receptor blockade in reducing LDL-peroxidation.
Spec (possible) Positive_regulation (role) of Negative_regulation (blockade) of AT1
2) Confidence 0.16 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2515419 Disease Relevance 0.76 Pain Relevance 0.10

General Comments

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