INT242227

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Context Info
Confidence 0.32
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.15
Pain Relevance 0.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (PLA2G2D)
Anatomy Link Frequency
mesangial cells 1
PLA2G2D (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 53 94.40 High High
COX-2 inhibitor 4 82.92 Quite High
rheumatoid arthritis 3 79.12 Quite High
Inflammatory stimuli 1 64.96 Quite High
Inflammatory response 3 60.96 Quite High
cINOD 8 56.60 Quite High
Pain 2 52.84 Quite High
Inflammatory mediators 3 46.56 Quite Low
cytokine 7 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 66 94.40 High High
Disease 9 93.88 High High
Myocardial Infarction 9 86.40 High High
Rheumatoid Arthritis 3 79.12 Quite High
Toxicity 3 62.64 Quite High
Rheumatic Diseases 5 54.40 Quite High
Pain 2 52.84 Quite High
Atherosclerosis 37 50.00 Quite Low
Stress 2 47.44 Quite Low
Injury 1 32.08 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Among the 10 human secreted PLA2s (sPLA2s) known to date, the most studied is the non-pancreatic Group IIA, denoted GIIAPLA2, because of its involvement in the pathogenesis of many inflammatory diseases (for a review, see [7]).
Localization (secreted) of sPLA2s associated with inflammation and disease
1) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2879362 Disease Relevance 0.86 Pain Relevance 0.43
Many cell types can secrete sPLA2s, especially sPLA2-IIA such as mesangial cells (Pfeilschifter et al 1989; Schalkwijk et al 1991), vascular smooth muscle (Nakano et al 1990; Kurihara et al 1991), endothelial cells (Murakami et al 1993), platelets (Hayakawa et al 1988), mast cells (Foneth et al 1994; Reddy et al 1996), neutrophils (Wright et al 1990), macrophages (Hidi et al 1993; Brabour et al 1993; Vial et al 1995), and hepatic cells (Crowl et al 1991).
Localization (secrete) of sPLA2s in mesangial cells
2) Confidence 0.27 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2515419 Disease Relevance 0.29 Pain Relevance 0.11

General Comments

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