INT24224

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Context Info
Confidence 0.67
First Reported 1987
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.15
Pain Relevance 1.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Rere) nucleus (Rere) DNA binding (Rere)
Anatomy Link Frequency
plasma 1
skin 1
hippocampus 1
Rere (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 1 100.00 Very High Very High Very High
Opioid 1 97.68 Very High Very High Very High
Hippocampus 3 96.76 Very High Very High Very High
qutenza 10 95.36 Very High Very High Very High
Endogenous opioid 3 88.32 High High
opioid receptor 2 75.00 Quite High
antagonist 2 75.00 Quite High
substance P 1 53.32 Quite High
Neuropeptide 2 25.00 Low Low
cva 1 18.00 Low Low
Disease Link Frequency Relevance Heat
Age-related Macular Degeneration 65 99.84 Very High Very High Very High
Hypertension 2 75.00 Quite High
Sprains And Strains 1 63.36 Quite High
Alopecia 1 60.48 Quite High
Ocular Toxicity (including Many Sub-types) 5 60.24 Quite High
Injury 2 59.32 Quite High
Eye Pain 1 15.44 Low Low
Ocular Injury 1 13.60 Low Low
Uveitis 55 5.00 Very Low Very Low Very Low
INFLAMMATION 18 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, in voluntary running rats there was a three-fold increase in the hippocampal levels of Met-enkephalin-Arg-Phe compared with non-runners, indicating an increase in opioid activity in the hippocampus during running.
Positive_regulation (increase) of Arg in hippocampus associated with hippocampus, enkephalin and opioid
1) Confidence 0.67 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 15078558 Disease Relevance 0.20 Pain Relevance 0.57
Intradermal injection of Arg-neurokinin B, a potent and water soluble derivative of neurokinin B, produced a similar plasma extravasation (Evans blue leakage technique) in the skin of vehicle- or capsaicin-pretreated rats. 7.
Positive_regulation (derivative) of Arg in skin associated with qutenza
2) Confidence 0.49 Published 1987 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 2449621 Disease Relevance 0.12 Pain Relevance 0.59
Another study demonstrated that the plasma complement C3a des Arg levels increased in AMD patients compared to controls [98].
Positive_regulation (increased) of Arg in plasma associated with age-related macular degeneration
3) Confidence 0.02 Published 2008 Journal Semin Immunopathol Section Body Doc Link PMC2315691 Disease Relevance 0.83 Pain Relevance 0

General Comments

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