INT24225

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Context Info
Confidence 0.62
First Reported 1987
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 93
Total Number 94
Disease Relevance 52.75
Pain Relevance 16.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (Alms1) cilium (Alms1) molecular_function (Alms1)
lipid metabolic process (Alms1) cytoplasm (Alms1)
Anatomy Link Frequency
brain 19
endothelial cells 5
central nervous system 2
neutrophil 2
microglia 2
Alms1 (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 1757 100.00 Very High Very High Very High
cytokine 248 100.00 Very High Very High Very High
glial activation 4 99.90 Very High Very High Very High
Multiple sclerosis 473 99.84 Very High Very High Very High
depression 18 99.82 Very High Very High Very High
Spinal cord 415 99.70 Very High Very High Very High
Inflammation 600 99.68 Very High Very High Very High
Neuropeptide 87 99.28 Very High Very High Very High
Morphine 113 99.12 Very High Very High Very High
Migraine 22 99.04 Very High Very High Very High
Disease Link Frequency Relevance Heat
Neuromyelitis Optica 1783 100.00 Very High Very High Very High
Multiple Sclerosis 850 100.00 Very High Very High Very High
Targeted Disruption 365 100.00 Very High Very High Very High
Adhesions 215 100.00 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 816 99.98 Very High Very High Very High
Cancer 551 99.98 Very High Very High Very High
Autoimmune Disease 254 99.92 Very High Very High Very High
Viral Meningitis 129 99.88 Very High Very High Very High
Demyelinating Disease 332 99.84 Very High Very High Very High
Glioblastoma 120 99.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Odontoblasts in vitro express tubulin, inversin, rootletin, OFD1, BBS4, BBS6, ALMS1, KIF3A, PC1, and PC2.
Gene_expression (express) of ALMS1 in Odontoblasts
1) Confidence 0.62 Published 2009 Journal J. Dent. Res. Section Abstract Doc Link 19783798 Disease Relevance 0.09 Pain Relevance 0.14
However, the ALMS1 protein has been shown to be ubiquitously expressed and to localize subcellularly [9].
Gene_expression (expressed) of ALMS1
2) Confidence 0.60 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC2266715 Disease Relevance 1.57 Pain Relevance 0.04
Identification of novel disease-causing ALMS1 mutation
Gene_expression (mutation) of ALMS1 associated with disease
3) Confidence 0.59 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC2266715 Disease Relevance 0.10 Pain Relevance 0
A schematic representation of the normal ALMS1 gene and the ALMS1 mutations causative of AS are shown in Figures 2, 3, 4.
Gene_expression (representation) of normal ALMS1 gene associated with alstrom syndrome
4) Confidence 0.59 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC2266715 Disease Relevance 1.93 Pain Relevance 0
Solid lipid nanoparticles consisting of microemulsions of solidified oil nanodroplets loaded with iron oxide and injected systemically into rats have been shown to cross the BBB and accumulate in the brain with long-lasting kinetics [16].
Gene_expression (cross) of BBB in brain
5) Confidence 0.50 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604882 Disease Relevance 0.25 Pain Relevance 0.19
A significant amount of work using nanotechnological approaches to crossing the BBB has focused on the delivery of antineoplastic drugs to CNS tumors.
Gene_expression (crossing) of BBB in CNS associated with cancer and central nervous system
6) Confidence 0.50 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604882 Disease Relevance 0.31 Pain Relevance 0.18
Although this ideal scenario has not yet been realized, a considerable body of work has been done to develop nanotechnological delivery strategies for crossing the BBB.


Gene_expression (crossing) of BBB in body
7) Confidence 0.50 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604882 Disease Relevance 0.28 Pain Relevance 0.18
Currently, most nanoengineered systems for crossing the BBB take advantage of drugs that are already in clinical use and therefore have greater potential for reaching the clinic relatively quickly.
Gene_expression (crossing) of BBB
8) Confidence 0.50 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604882 Disease Relevance 0 Pain Relevance 0.11
Ideally, methods for crossing the BBB will complement other nanotechnological tools being developed to study the CNS, including quantum dot labeling and imaging [20].


Gene_expression (crossing) of BBB associated with central nervous system and imagery
9) Confidence 0.50 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604882 Disease Relevance 0 Pain Relevance 0.28
For other applications, molecules other than drugs must cross the BBB for therapeutic or diagnostic reasons, including oligonucleotides, genes, and contrast agents.
Gene_expression (cross) of BBB
10) Confidence 0.50 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604882 Disease Relevance 0.33 Pain Relevance 0.33
There are a limited number of mechanisms by which substances cross the BBB.
Gene_expression (cross) of BBB
11) Confidence 0.41 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604887 Disease Relevance 0.25 Pain Relevance 0.51
The development of drugs that can cross the BBB is one of the greatest challenges in medicine today.
Gene_expression (cross) of BBB
12) Confidence 0.41 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604887 Disease Relevance 1.00 Pain Relevance 0.26
Small, enzymatically stable peptides are capable of crossing the BBB even in the absence of a saturable transporter in amounts sufficient to affect CNS function.
Gene_expression (crossing) of BBB associated with central nervous system
13) Confidence 0.41 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604887 Disease Relevance 0 Pain Relevance 0.33
P-glycoprotein (P-gp) and organic anion transporting polypeptides (Oatp) are expressed at the blood-brain barrier (BBB).
Gene_expression (expressed) of BBB in brain
14) Confidence 0.37 Published 2001 Journal Neurosci. Lett. Section Abstract Doc Link 11257421 Disease Relevance 0 Pain Relevance 0.30
Ten minutes following FUS-MB, mice received Trypan blue or Evans blue (0.06 ml, 4%, IV), which are used interchangeably for BBB studies.
Gene_expression (studies) of BBB
15) Confidence 0.34 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2364662 Disease Relevance 0.07 Pain Relevance 0.13
DISRUPTING THE BBB
Gene_expression (DISRUPTING) of BBB
16) Confidence 0.21 Published 2008 Journal Indian Journal of Pharmaceutical Sciences Section Body Doc Link PMC2792490 Disease Relevance 0.30 Pain Relevance 0.08
Examination of capillary ultrastructure revealed endothelial cell degeneration, which, along with astrocyte alteration, compromised the BBB and BSCB.
Gene_expression (compromised) of BBB in capillary
17) Confidence 0.21 Published 2007 Journal PLoS ONE Section Abstract Doc Link PMC2075163 Disease Relevance 0.34 Pain Relevance 0.17
Recently, Vos et al. [15] demonstrated that BBB dysfunction in MS patients is apparent not only in focal lesions but also in diffuse abnormalities in white matter which were detected by postmortem MRI.
Gene_expression (dysfunction) of BBB in white matter associated with multiple sclerosis and congenital anomalies
18) Confidence 0.21 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2075163 Disease Relevance 1.18 Pain Relevance 0.42
Furthermore, efflux transporter proteins expressed at the BBB, such as P-glycoprotein (Pgp1) [1], present significant problems for the treatment of brain tumors with current chemotherapeutics [12] as they act to pump small hydrophobic chemotherapeutic agents out of the brain.
Gene_expression (expressed) of BBB in brain associated with brain tumor
19) Confidence 0.20 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2424243 Disease Relevance 0.17 Pain Relevance 0
Liu et al., however, showed that rapid brain equilibration is not the same as high BBB permeability, since a higher level of nonspecific binding in the brain due to higher lipophilicity will increase the time to reach equilibrium (5).
Gene_expression (permeability) of BBB in brain
20) Confidence 0.19 Published 2007 Journal Pharm Res Section Body Doc Link PMC2469271 Disease Relevance 0 Pain Relevance 0.13

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