INT24234

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Context Info
Confidence 0.34
First Reported 1988
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.32
Pain Relevance 0.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Mtx1)
Anatomy Link Frequency
external 2
Mtx1 (Mus musculus)
Pain Link Frequency Relevance Heat
methotrexate 70 100.00 Very High Very High Very High
gABA 5 100.00 Very High Very High Very High
tetrodotoxin 1 99.34 Very High Very High Very High
Glutamate 2 86.36 High High
Calcium channel 1 75.00 Quite High
antagonist 2 70.88 Quite High
Arthritis 27 50.00 Quite Low
adenocard 8 37.36 Quite Low
Inflammation 2 31.44 Quite Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 11 82.24 Quite High
Toxicity 22 64.56 Quite High
Death 1 59.52 Quite High
Body Weight 1 58.96 Quite High
Cancer 2 58.80 Quite High
Juvenile Chronic Polyarthritis 23 50.00 Quite Low
INFLAMMATION 2 31.44 Quite Low
Rheumatic Diseases 1 25.80 Quite Low
Disease 11 5.00 Very Low Very Low Very Low
Adverse Drug Reaction 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The initial target of MTX to be identified was dihydrofolate reductase (DHFR), which forms tetrahydrofolate, a precursor required for one carbon donation for synthesis of thymidylate, purines, methionine and serine, remethylation of homocysteine to form methionine, and provision of methyl donors for multiple methyltransferase enzymes [29].
Positive_regulation (required) of Localization (target) of MTX associated with methotrexate
1) Confidence 0.34 Published 2010 Journal Human Genomics and Proteomics : HGP Section Body Doc Link PMC2958653 Disease Relevance 0.32 Pain Relevance 0.41
Whereas 500 nM tetrodotoxin was without significant effect, MTX-evoked GABA release was dependent on the presence of external Na+ and sensitive to nipecotic acid, a GABA uptake inhibitor.
Positive_regulation (dependent) of Localization (release) of MTX in external associated with tetrodotoxin and gaba
2) Confidence 0.08 Published 1988 Journal J. Neurochem. Section Abstract Doc Link 2450172 Disease Relevance 0 Pain Relevance 0.36

General Comments

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