INT242353

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Context Info
Confidence 0.03
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 3.31
Pain Relevance 2.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
body 1
Tcas1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
sSRI 116 100.00 Very High Very High Very High
antidepressant 77 100.00 Very High Very High Very High
tricyclic antidepressant 41 100.00 Very High Very High Very High
Endep 2 100.00 Very High Very High Very High
Serotonin 20 98.56 Very High Very High Very High
fluoxetine 27 96.72 Very High Very High Very High
depression 112 95.96 Very High Very High Very High
sNRI 38 94.96 High High
Duloxetine 39 89.04 High High
headache 3 66.40 Quite High
Disease Link Frequency Relevance Heat
Weight Gain 4 99.28 Very High Very High Very High
Depression 134 95.96 Very High Very High Very High
Panic Disorder 39 94.52 High High
Body Weight 4 91.04 High High
Anxiety Disorder 16 88.52 High High
Sleep Disorders 13 85.68 High High
Dizziness 7 83.40 Quite High
Suicidal Behaviour 3 80.28 Quite High
Weight Loss 2 77.04 Quite High
Syndrome 4 71.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increasing evidence of the importance of NE in the etiology of depression10 and the idea that “two actions are better than one” have led to the development of a new class of compounds that block the reuptake of both 5-HT and NE without the nonspecific, side effect-inducing receptor interactions of TCAs.
TCAs Binding (interactions) of associated with tricyclic antidepressant
1) Confidence 0.03 Published 2010 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2938282 Disease Relevance 0.31 Pain Relevance 0.63
In fact, the affinity of TCAs for a number of central receptors including muscarinic cholinergic and histaminergic receptors makes them not recommended as first-line choice for treatment of PSD.
TCAs Binding (affinity) of associated with depression
2) Confidence 0.03 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2515899 Disease Relevance 0.74 Pain Relevance 0.55
In particular, some TCAs including amitriptyline, certain SSRIs including paroxetine, and other antidepressants, such as mirtazapine, are frequently associated with significant weight gain.28 Data from a wide range of clinical trials29 have shown that 82% of patients taking milnacipran 100 mg/day for 3 months or more have no clinically significant weight change (defined as >5% of body weight).
TCAs Binding (associated) of in body associated with antidepressant, body weight, weight gain, ssri, endep and tricyclic antidepressant
3) Confidence 0.03 Published 2010 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2938282 Disease Relevance 1.25 Pain Relevance 0.60
However, TCAs are associated with potentially fatal arrhythmias, either in monotherapy or in combination with fluoxetine (Witchel et al) and MAO inhibitors must be used with caution in many populations (Yamada and Yasuhara 2004).
TCAs Binding (associated) of associated with tricyclic antidepressant and fluoxetine
4) Confidence 0.01 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2656325 Disease Relevance 1.01 Pain Relevance 0.45

General Comments

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