INT24236

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Context Info
Confidence 0.61
First Reported 1988
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 19
Disease Relevance 3.68
Pain Relevance 4.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Th) mitochondrion (Th) oxidoreductase activity (Th)
nucleus (Th) cytoplasm (Th)
Anatomy Link Frequency
striatum 6
PP2A 4
Th (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 446 100.00 Very High Very High Very High
antagonist 204 99.98 Very High Very High Very High
Nucleus accumbens 26 99.92 Very High Very High Very High
adenocard 262 99.72 Very High Very High Very High
Catecholamine 76 99.52 Very High Very High Very High
Ventral tegmentum 33 99.16 Very High Very High Very High
Enkephalin 3 98.58 Very High Very High Very High
addiction 36 95.64 Very High Very High Very High
Dynorphin 2 83.76 Quite High
Eae 121 76.32 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 86 99.72 Very High Very High Very High
Disease 106 96.64 Very High Very High Very High
Parkinson's Disease 164 96.00 Very High Very High Very High
Drug Dependence 21 95.84 Very High Very High Very High
Aging 28 95.80 Very High Very High Very High
Catalepsy 7 88.40 High High
Pheochromocytoma 1 76.88 Quite High
Cancer 2 75.12 Quite High
Neuroblastoma 1 60.08 Quite High
Neurological Disease 7 57.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Differences in tyrosine hydroxylase (TH) immunoreactivity could not account for these findings, but phosphorylation of TH at Ser40, but not Ser31, was enhanced in aged Pdyn KO mice.
Positive_regulation (enhanced) of Phosphorylation (phosphorylation) of TH associated with targeted disruption
1) Confidence 0.61 Published 2009 Journal Exp. Neurol. Section Abstract Doc Link 19500577 Disease Relevance 0.70 Pain Relevance 0.37
Differences in tyrosine hydroxylase (TH) immunoreactivity could not account for these findings, but phosphorylation of TH at Ser40, but not Ser31, was enhanced in aged Pdyn KO mice.
Positive_regulation (enhanced) of Phosphorylation (phosphorylation) of TH associated with targeted disruption
2) Confidence 0.50 Published 2009 Journal Exp. Neurol. Section Abstract Doc Link 19500577 Disease Relevance 0.71 Pain Relevance 0.37
Chronic treatment with caffeine and SCH58261 increased TH phosphorylation at Ser31 in the striatum
Positive_regulation (increased) of Phosphorylation (phosphorylation) of TH in striatum
3) Confidence 0.50 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2843608 Disease Relevance 0 Pain Relevance 0.18
Chronic treatments with low dose caffeine (10 mg/kg) or SCH58261 (2 mg/kg) increased the concentrations of dopamine, DOPAC and HVA, concomitant with increased TH phosphorylation at Ser31 and consequently enhanced TH activity in the striatal tissues in both caffeine- and SCH58261-sensitized mice.
Positive_regulation (increased) of Phosphorylation (phosphorylation) of TH associated with dopamine
4) Confidence 0.38 Published 2010 Journal J Biomed Sci Section Abstract Doc Link PMC2843608 Disease Relevance 0 Pain Relevance 0.51
As shown in Fig 4, Western blotting demonstrated a statistically significant increase in the proportion of TH phosphorylation at Ser31 after caffeine and SCH58261 treatment (P < 0.01 for caffeine-treated group and P < 0.05 for SCH58261-treated group).
Positive_regulation (increase) of Phosphorylation (phosphorylation) of TH
5) Confidence 0.38 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2843608 Disease Relevance 0 Pain Relevance 0.09
Our results also showed that chronic treatments with caffeine and SCH58261 increased the dopamine concentration and TH phosphorylation at Ser31 in the striatum in caffeine- and SCH58261-sensitized mice.
Positive_regulation (increased) of Phosphorylation (phosphorylation) of TH in striatum associated with dopamine
6) Confidence 0.38 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2843608 Disease Relevance 0.22 Pain Relevance 0.42
The elevation of DA and its metabolites were associated with the enhanced phosphorylation of tyrosine hydroxylase at Ser31, the active form and rate-limiting enzyme in catecholamine biosynthesis.
Positive_regulation (enhanced) of Phosphorylation (phosphorylation) of tyrosine hydroxylase associated with catecholamine
7) Confidence 0.38 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2843608 Disease Relevance 0.12 Pain Relevance 0.47
We also demonstrated that chronic treatment of caffeine and a selective A2A antagonist enhance the phosphorylation level of tyrosine hydroxylase at Ser31.
Positive_regulation (enhance) of Phosphorylation (phosphorylation) of tyrosine hydroxylase associated with antagonist
8) Confidence 0.38 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2843608 Disease Relevance 0.12 Pain Relevance 0.39
Our findings, together with previous studies, make it plausible that caffeine through adenosine A2A receptor-mediated phosphorylation of TH at Ser31, results in the dopaminergic neuroadaptations related to the treatment of PD and mechanism of drug dependence/addiction.
Positive_regulation (mediated) of Phosphorylation (phosphorylation) of TH associated with drug dependence, addiction, adenocard and disease
9) Confidence 0.36 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2843608 Disease Relevance 0.25 Pain Relevance 0.78
Phosphorylation of TH stimulates its activity, an effect that is reversed by protein phosphatase 2A (PP2A).
Positive_regulation (stimulates) of Phosphorylation (Phosphorylation) of TH in PP2A
10) Confidence 0.33 Published 2010 Journal The Journal of Biological Chemistry Section Abstract Doc Link PMC2878529 Disease Relevance 0.09 Pain Relevance 0.13
Or dephosphorylation of TH may be stimulated by PKC?
Positive_regulation (by) of Phosphorylation (dephosphorylation) of TH
11) Confidence 0.33 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2878529 Disease Relevance 0.23 Pain Relevance 0.11
To evaluate if in vivo overexpression of a-Syn altered TH phosphorylation, we compared striatal immunoblots from homozygous WT a-Syn-overexpressing TH-promoter mice (WT-Syn++) to non-transgenic control mice (Non-Tg) in the same genetic background in which total a-Syn overexpression is ?
Positive_regulation (overexpression) of Phosphorylation (phosphorylation) of TH associated with targeted disruption
12) Confidence 0.30 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2878529 Disease Relevance 0.27 Pain Relevance 0.04
This possibility is also supported by findings by others in which RNAi-mediated silencing of endogenous a-Syn led to increased levels of TH phosphorylation, TH activity, and dopamine in MN9D cells (8).
Positive_regulation (increased) of Phosphorylation (phosphorylation) of TH associated with dopamine
13) Confidence 0.30 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2878529 Disease Relevance 0 Pain Relevance 0.05
Phosphorylated tyrosine hydroxylase (a marker for dopamine production) was significantly elevated in ZI and higher in VTA (although not significantly) in neglectful mice.
Positive_regulation (elevated) of Phosphorylation (Phosphorylated) of tyrosine hydroxylase associated with ventral tegmentum and dopamine
14) Confidence 0.30 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2276864 Disease Relevance 0 Pain Relevance 0.52
It has been demonstrated that TH activation requires TH-Ser-40 phosphorylation; thus, we also measured Ser(P)-40 levels in mouse striatum.
Positive_regulation (requires) of Phosphorylation (phosphorylation) of TH-Ser in striatum
15) Confidence 0.29 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2878529 Disease Relevance 0.22 Pain Relevance 0
Conversely, a-Syn knock-out mice had elevated TH-Ser-19 phosphorylation and activity and less active PP2A in dopaminergic tissues.
Positive_regulation (elevated) of Phosphorylation (phosphorylation) of TH-Ser in PP2A associated with targeted disruption
16) Confidence 0.29 Published 2010 Journal The Journal of Biological Chemistry Section Abstract Doc Link PMC2878529 Disease Relevance 0.16 Pain Relevance 0.11
In vivo, a-Syn may also bind particular PP2A B subunits that contribute to TH dephosphorylation (83).
Positive_regulation (contribute) of Phosphorylation (dephosphorylation) of TH
17) Confidence 0.27 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2878529 Disease Relevance 0.12 Pain Relevance 0.13
A recent report in transduced MN9D cells overexpressing the a-Syn S129D phosphomimic saw an increase in TH-Ser(P)-40 phosphorylation (107).
Positive_regulation (increase) of Phosphorylation (phosphorylation) of TH-Ser
18) Confidence 0.27 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2878529 Disease Relevance 0.27 Pain Relevance 0.04
[D-Ala2,D-Leu5]-enkephalin, which decreased cyclic AMP levels and reversed the 2-chloroadenosine-stimulated phosphorylation of tyrosine hydroxylase in differentiated PC12 cells, also reversed the stimulation of phosphorylation of the 90-kDa protein in NCB-20 cells.
Positive_regulation (stimulated) of Phosphorylation (phosphorylation) of tyrosine hydroxylase associated with enkephalin
19) Confidence 0.08 Published 1988 Journal J. Neurochem. Section Abstract Doc Link 2450174 Disease Relevance 0.21 Pain Relevance 0.14

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