INT24239

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Context Info
Confidence 0.18
First Reported 1988
Last Reported 1988
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.31
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Pkia) kinase activity (Pkia) cytoplasm (Pkia)
Pkia (Mus musculus)
Pain Link Frequency Relevance Heat
Nerve growth factor 2 92.48 High High
Enkephalin 2 74.48 Quite High
adenocard 4 25.00 Low Low
Disease Link Frequency Relevance Heat
Pheochromocytoma 2 94.84 High High
Neuroblastoma 2 78.04 Quite High
Cancer 4 72.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
When NCB-20 cells were exposed to activators [5-hydroxytryptamine (5-HT), prostaglandin E1, or forskolin], resulting in activation of cyclic AMP-dependent protein kinase, increased 32P incorporation into two major proteins [130 kilodaltons (kDa) and 90 kDa] occurred. 5-HT (in the presence of phosphodiesterase inhibitor, isobutylmethylxanthine) gave a three- to fourfold increase, and forskolin a four- to sevenfold increase in 32P incorporation into the 90-kDa protein.
Positive_regulation (activation) of cyclic AMP-dependent protein kinase
1) Confidence 0.18 Published 1988 Journal J. Neurochem. Section Abstract Doc Link 2450174 Disease Relevance 0.17 Pain Relevance 0.12
In contrast, an 80-kDa protein is the primary substrate for calcium/phospholipid-dependent protein kinase, and its phosphorylation is inhibited by agents that elevate cyclic AMP levels and thereby activate cyclic AMP-dependent protein kinase.
Positive_regulation (activate) of cyclic AMP-dependent protein kinase
2) Confidence 0.18 Published 1988 Journal J. Neurochem. Section Abstract Doc Link 2450174 Disease Relevance 0.13 Pain Relevance 0

General Comments

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