INT242402

Context Info Confidence 0.17 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 1.44 Pain Relevance 0.45

signal transducer activity (Bdkrb1, Hmox1) signal transduction (Bdkrb1, Hmox1) endoplasmic reticulum (Hmox1) enzyme binding (Hmox1) cytosol (Hmox1) cell death (Hmox1)

Bdkrb1 (Mus musculus) Hmox1 (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 24 93.32 agonist 5 90.64 cytokine 6 87.64 antagonist 7 83.68 ischemia 13 62.64 bradykinin 10 53.64 Inflammatory response 4 5.00 chemokine 2 5.00 ketamine 1 5.00 anesthesia 1 5.00

Disease Link Frequency Relevance Heat Targeted Disruption 10 95.76 INFLAMMATION 29 93.32 Reperfusion Injury 32 79.40 Apoptosis 6 75.64 Injury 2 64.24 Cv Unclassified Under Development 12 62.64 Death 6 55.68 Pressure And Volume Under Development 2 5.00 Renal Disease 2 5.00 Aggression 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

We previously have observed that B1R deletion increased HO-1 and decreased MCP-1 expression [27].

Negative_regulation (deletion) of B1R Positive_regulation (increased) of HO-1

1) Confidence 0.17 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2516176 Disease Relevance 1.44 Pain Relevance 0.45

General Comments

This test has worked.