INT24241

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Context Info
Confidence 0.81
First Reported 1988
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 35
Total Number 74
Disease Relevance 8.69
Pain Relevance 16.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Th) mitochondrion (Th) oxidoreductase activity (Th)
nucleus (Th) cytoplasm (Th)
Anatomy Link Frequency
striatum 12
internal 2
substantia nigra 2
PP2A 2
brain 1
Th (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 7 100.00 Very High Very High Very High
Nucleus accumbens 264 99.92 Very High Very High Very High
antagonist 506 99.74 Very High Very High Very High
Dopamine 1986 99.62 Very High Very High Very High
adenocard 654 99.54 Very High Very High Very High
Catecholamine 308 99.52 Very High Very High Very High
Neurotransmitter 40 99.44 Very High Very High Very High
Substantia nigra 426 99.14 Very High Very High Very High
Ventral tegmentum 207 98.96 Very High Very High Very High
Eae 315 98.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 9 100.00 Very High Very High Very High
Targeted Disruption 406 99.54 Very High Very High Very High
Parkinson's Disease 766 97.48 Very High Very High Very High
Disease 319 96.64 Very High Very High Very High
Drug Dependence 51 95.84 Very High Very High Very High
Aging 124 95.32 Very High Very High Very High
Catalepsy 17 88.40 High High
Stress 97 83.12 Quite High
Neurological Disease 17 80.32 Quite High
Toxicity 80 77.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Differences in tyrosine hydroxylase (TH) immunoreactivity could not account for these findings, but phosphorylation of TH at Ser40, but not Ser31, was enhanced in aged Pdyn KO mice.
Phosphorylation (phosphorylation) of TH associated with targeted disruption
1) Confidence 0.81 Published 2009 Journal Exp. Neurol. Section Abstract Doc Link 19500577 Disease Relevance 0.70 Pain Relevance 0.37
Differences in tyrosine hydroxylase (TH) immunoreactivity could not account for these findings, but phosphorylation of TH at Ser40, but not Ser31, was enhanced in aged Pdyn KO mice.
Phosphorylation (phosphorylation) of TH associated with targeted disruption
2) Confidence 0.72 Published 2009 Journal Exp. Neurol. Section Abstract Doc Link 19500577 Disease Relevance 0.69 Pain Relevance 0.36
In agreement with higher levels of phosphorylation of TH, we also find increased levels of phosphorylation of DARPP-32.
Phosphorylation (phosphorylation) of TH
3) Confidence 0.60 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2276864 Disease Relevance 0 Pain Relevance 0.33
The phosphorylation of TH is involved in the short term regulation of this enzyme [46] and although TH can be phosphorylated at Ser8, Ser19, Ser31, and Ser40, the phosphorylation of TH at Ser40 (examined here) is correlated with the greatest increase in dopamine synthesis and release [47]–[50].
Phosphorylation (phosphorylation) of TH associated with dopamine
4) Confidence 0.60 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2276864 Disease Relevance 0 Pain Relevance 0.61
Neglectful females show region specific differences in c-Fos, phosphorylated tyrosine hydroxylase (pTH), and phosphorylated DARPP-32 (pDARPP-32) expression compared to their nurturing counterparts.
Phosphorylation (s in c-Fos, ph) of tyrosine hydroxylase
5) Confidence 0.60 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2276864 Disease Relevance 0 Pain Relevance 0.07
7) express greater serine 40 (ser40) phosphorylated TH immunoreactive (pTH-ir) cell and fiber area compared to nurturing females (N?
Phosphorylation (phosphorylated) of pTH
6) Confidence 0.60 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2276864 Disease Relevance 0 Pain Relevance 0.12
7) express greater serine 40 (ser40) phosphorylated TH immunoreactive (pTH-ir) cell and fiber area compared to nurturing females (N?
Phosphorylation (phosphorylated) of TH
7) Confidence 0.60 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2276864 Disease Relevance 0 Pain Relevance 0.12
Neglectful females show region specific differences in c-Fos, phosphorylated tyrosine hydroxylase (pTH), and phosphorylated DARPP-32 (pDARPP-32) expression compared to their nurturing counterparts.
Phosphorylation (phosphorylated) of pTH
8) Confidence 0.60 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2276864 Disease Relevance 0 Pain Relevance 0.07
Our findings, together with previous studies, make it plausible that caffeine through adenosine A2A receptor-mediated phosphorylation of TH at Ser31, results in the dopaminergic neuroadaptations related to the treatment of PD and mechanism of drug dependence/addiction.
Phosphorylation (phosphorylation) of TH associated with drug dependence, addiction, adenocard and disease
9) Confidence 0.59 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2843608 Disease Relevance 0.25 Pain Relevance 0.78
In conclusion, our study demonstrates that low dosages of caffeine and a selective adenosine A2A antagonist SCH58261 induce sensitization and cross-sensitization of locomotor activity, which are associated with elevated dopamine concentration and phosphorylation of TH at Ser31 in the striatum.
Phosphorylation (phosphorylation) of TH in striatum associated with dopamine, adenocard, eae and antagonist
10) Confidence 0.59 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2843608 Disease Relevance 0.18 Pain Relevance 0.62
Chronic treatment with caffeine and SCH58261 increased TH phosphorylation at Ser31 in the striatum
Phosphorylation (phosphorylation) of TH in striatum
11) Confidence 0.59 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2843608 Disease Relevance 0 Pain Relevance 0.18
To assess if PP2A dephosphorylates TH-Ser(P)-19 in our cells, we first treated untransfected MN9D cells with okadaic acid and measured Ser(P)-19 levels by immunoblot.
Phosphorylation (dephosphorylates) of TH-Ser
12) Confidence 0.54 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2878529 Disease Relevance 0 Pain Relevance 0
To evaluate if in vivo overexpression of a-Syn altered TH phosphorylation, we compared striatal immunoblots from homozygous WT a-Syn-overexpressing TH-promoter mice (WT-Syn++) to non-transgenic control mice (Non-Tg) in the same genetic background in which total a-Syn overexpression is ?
Phosphorylation (phosphorylation) of TH associated with targeted disruption
13) Confidence 0.54 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2878529 Disease Relevance 0.26 Pain Relevance 0.04
These mice are healthy with no overt nigrostriatal pathology (46), thus allowing for systematically analyzing TH phosphorylation and TH activity in healthy dopaminergic tissues that are relevant to PD.
Spec (analyzing) Phosphorylation (phosphorylation) of TH associated with parkinson's disease
14) Confidence 0.54 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2878529 Disease Relevance 0.37 Pain Relevance 0.13
Or dephosphorylation of TH may be stimulated by PKC?
Phosphorylation (dephosphorylation) of TH
15) Confidence 0.54 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2878529 Disease Relevance 0.18 Pain Relevance 0.11
To directly measure the impact of Ser-129 phosphorylation of a-Syn on PP2A and TH, we used recombinant proteins and cell-free assays.


Phosphorylation (phosphorylation) of TH
16) Confidence 0.54 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2878529 Disease Relevance 0 Pain Relevance 0.07
These data identify a close relationship between a-Syn levels and TH phosphorylation in vivo, which prompted us to measure for changes in TH activity.


Phosphorylation (phosphorylation) of TH
17) Confidence 0.54 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2878529 Disease Relevance 0.06 Pain Relevance 0
These findings raised the possibility that phosphorylation of other TH serines might be similarly affected by a-Syn overexpression.
Phosphorylation (phosphorylation) of TH
18) Confidence 0.54 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2878529 Disease Relevance 0.48 Pain Relevance 0.03
Phosphorylation of TH stimulates its activity, an effect that is reversed by protein phosphatase 2A (PP2A).
Phosphorylation (Phosphorylation) of TH in PP2A
19) Confidence 0.54 Published 2010 Journal The Journal of Biological Chemistry Section Abstract Doc Link PMC2878529 Disease Relevance 0.09 Pain Relevance 0.13
To assess the potential contribution of a-Syn phosphorylation on TH and PP2A activity in a physiological model, we next evaluated MN9D cells after transient transfection with wild type or Ser-129 mutant a-Syn.


Phosphorylation (phosphorylation) of TH
20) Confidence 0.54 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2878529 Disease Relevance 0.07 Pain Relevance 0.03

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