INT242414

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Context Info
Confidence 0.23
First Reported 2008
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.82
Pain Relevance 1.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Aes)
Anatomy Link Frequency
knee 1
Aes (Rattus norvegicus)
Pain Link Frequency Relevance Heat
sodium channel 15 99.32 Very High Very High Very High
Pain 37 98.66 Very High Very High Very High
anticonvulsant 17 95.00 High High
carbamazepine 18 79.80 Quite High
Osteoarthritis 28 78.60 Quite High
Analgesic 7 30.64 Quite Low
Potency 1 29.52 Quite Low
corticosteroid 6 28.88 Quite Low
COX-2 inhibitor 2 26.80 Quite Low
aspirin 2 25.04 Quite Low
Disease Link Frequency Relevance Heat
Anxiety Disorder 3 98.84 Very High Very High Very High
Pain 36 98.66 Very High Very High Very High
Critical Illness 6 87.20 High High
Anaemia 1 84.56 Quite High
Osteoarthritis 31 78.60 Quite High
Hyponatremia 2 75.40 Quite High
Death 46 69.68 Quite High
Heart Rate Under Development 2 63.92 Quite High
Vomiting 5 63.28 Quite High
Diplopia 3 61.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Other outcomes such as pain, anxiety or functional status, which may be more sensitive to the effect of AEs and preventable AEs, might be more relevant to patients.
Regulation (effect) of AEs associated with pain and anxiety disorder
1) Confidence 0.23 Published 2008 Journal BMC Health Serv Res Section Body Doc Link PMC2621200 Disease Relevance 0.28 Pain Relevance 0.17
Second, safety strategies need to target the most frequent and clinically important AEs for the most efficient use of resources.
Regulation (target) of AEs
2) Confidence 0.23 Published 2008 Journal BMC Health Serv Res Section Body Doc Link PMC2621200 Disease Relevance 0.07 Pain Relevance 0
Other outcomes such as pain, anxiety or functional status, which may be more sensitive to the effect of AEs and preventable AEs, might be more relevant to patients.
Regulation (effect) of AEs associated with pain and anxiety disorder
3) Confidence 0.23 Published 2008 Journal BMC Health Serv Res Section Body Doc Link PMC2621200 Disease Relevance 0.28 Pain Relevance 0.17
This is an important point since AEDs with a similar mechanism (sodium channel blockade) might have an additive effect on observed AEs.
Spec (might) Regulation (effect) of AEs associated with sodium channel
4) Confidence 0.17 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2857610 Disease Relevance 0.51 Pain Relevance 0.18
During the study, seven patients were lost to follow-up, six withdrew due to target knee AEs, two became ineligible to continue, one withdrew consent and three patients discontinued from the study for other reasons.
Regulation (target) of AEs in knee
5) Confidence 0.10 Published 2008 Journal Knee Surg Sports Traumatol Arthrosc Section Body Doc Link PMC2516182 Disease Relevance 0.67 Pain Relevance 0.63

General Comments

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