INT24242

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Context Info
Confidence 0.38
First Reported 1988
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 9
Disease Relevance 1.44
Pain Relevance 0.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Th) mitochondrion (Th) oxidoreductase activity (Th)
nucleus (Th) cytoplasm (Th)
Anatomy Link Frequency
neurons 2
striatum 2
brain 2
dopaminergic neurons 2
Th (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 7 100.00 Very High Very High Very High
Enkephalin 1 99.20 Very High Very High Very High
Central nervous system 15 98.24 Very High Very High Very High
Catecholamine 42 93.76 High High
Substantia nigra 65 87.36 High High
Dopamine 144 86.72 High High
Nerve growth factor 1 75.76 Quite High
Spinal cord 32 49.20 Quite Low
adenocard 9 25.00 Low Low
midbrain 28 19.52 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 9 100.00 Very High Very High Very High
Parkinson's Disease 132 97.80 Very High Very High Very High
Targeted Disruption 70 86.80 High High
Stress 18 83.12 Quite High
Pheochromocytoma 1 78.12 Quite High
Toxicity 14 77.52 Quite High
Cancer 2 75.12 Quite High
Aging 21 69.16 Quite High
Neuroblastoma 1 61.32 Quite High
Disease 48 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To determine whether reduced TH phosphorylation reflected changes in TH enzymatic activity in striatum, we evaluated 15 mice per condition using a well characterized TH activity assay with minor modifications.
Spec (whether) Negative_regulation (reduced) of Spec (whether) Phosphorylation (phosphorylation) of TH in striatum
1) Confidence 0.38 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2878529 Disease Relevance 0 Pain Relevance 0
Together these findings strongly suggest that overexpression of a-Syn in TH-promoter mouse dopaminergic tissues reduced TH phosphorylation at TH-Ser(P)-19 and TH-Ser(P)-40, resulting in lower TH activity.
Negative_regulation (reduced) of Phosphorylation (phosphorylation) of TH
2) Confidence 0.33 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2878529 Disease Relevance 0 Pain Relevance 0.03
Using WT-Syn lentivirus in ASKO mice, we previously showed that TH phosphorylation is reduced when soluble a-Syn levels increase in dopaminergic neurons (48).
Negative_regulation (reduced) of Phosphorylation (phosphorylation) of TH in dopaminergic neurons
3) Confidence 0.28 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2878529 Disease Relevance 0 Pain Relevance 0.07
Here we demonstrate that a-Syn significantly inhibited TH activity in vitro and in vivo and that phosphorylation of a-Syn serine 129 (Ser-129) modulated this effect.
Negative_regulation (inhibited) of Phosphorylation (phosphorylation) of TH
4) Confidence 0.28 Published 2010 Journal The Journal of Biological Chemistry Section Abstract Doc Link PMC2878529 Disease Relevance 0.15 Pain Relevance 0.13
In MN9D cells, a-Syn overexpression reduced TH serine 19 phosphorylation (Ser(P)-19).
Negative_regulation (reduced) of Phosphorylation (phosphorylation) of TH
5) Confidence 0.28 Published 2010 Journal The Journal of Biological Chemistry Section Abstract Doc Link PMC2878529 Disease Relevance 0.15 Pain Relevance 0.13
When we assessed if higher levels of a-Syn expression correlated strongly with lower TH phosphorylation in individual WT-Syn++ mice, we found a significant negative correlation.
Negative_regulation (lower) of Phosphorylation (phosphorylation) of TH
6) Confidence 0.25 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2878529 Disease Relevance 0.13 Pain Relevance 0
a-Syn overexpression in WT-Syn++ and A53T-Syn++ mice reduced TH-Ser-19 phosphorylation in vivo, suggesting that, as in dopaminergic cell lines, both forms of a-Syn regulate TH similarly in the brain.
Negative_regulation (reduced) of Phosphorylation (phosphorylation) of TH-Ser in brain
7) Confidence 0.25 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2878529 Disease Relevance 0.38 Pain Relevance 0.16
We observed alpha-synuclein accumulation, phosphorylation, and inflammatory signs and loss of nigral TH+ neurons in our treated mice after 3 months of the treatment.
Negative_regulation (loss) of Phosphorylation (phosphorylation) of TH in neurons associated with inflammation
8) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808242 Disease Relevance 0.40 Pain Relevance 0.24
[D-Ala2,D-Leu5]-enkephalin, which decreased cyclic AMP levels and reversed the 2-chloroadenosine-stimulated phosphorylation of tyrosine hydroxylase in differentiated PC12 cells, also reversed the stimulation of phosphorylation of the 90-kDa protein in NCB-20 cells.
Negative_regulation (reversed) of Phosphorylation (phosphorylation) of tyrosine hydroxylase associated with enkephalin
9) Confidence 0.09 Published 1988 Journal J. Neurochem. Section Abstract Doc Link 2450174 Disease Relevance 0.21 Pain Relevance 0.14

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