INT242443

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Context Info
Confidence 0.09
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.66
Pain Relevance 0.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (Alms1) cilium (Alms1) molecular_function (Alms1)
lipid metabolic process (Alms1) cytoplasm (Alms1)
Anatomy Link Frequency
T cells 2
Alms1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 14 98.30 Very High Very High Very High
Central nervous system 60 96.64 Very High Very High Very High
Analgesic 1 88.72 High High
cva 1 60.16 Quite High
imagery 12 49.48 Quite Low
Hippocampus 12 5.00 Very Low Very Low Very Low
Glutamate 4 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
Glutamate receptor 3 5.00 Very Low Very Low Very Low
cerebral cortex 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 14 98.30 Very High Very High Very High
Toxicity 10 98.08 Very High Very High Very High
Disorder Of Lipid Metabolism 2 81.12 Quite High
Cerebral Malaria 5 78.96 Quite High
Pressure And Volume Under Development 1 61.76 Quite High
Hemorrhage 1 60.16 Quite High
Infection 12 56.76 Quite High
Multiple Sclerosis 21 56.36 Quite High
Stress 17 42.52 Quite Low
Sprains And Strains 4 20.20 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These Db:VP2121–130 epitope specific CD8 T cells then utilize perforin to deliver inflammatory components which ultimately result in activation of cellular components of the NVU, leading to rapid alteration of BBB tight junction proteins.
Positive_regulation (leading) of Localization (alteration) of BBB in T cells associated with inflammation
1) Confidence 0.09 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2516328 Disease Relevance 0.41 Pain Relevance 0.33
Thus, Calvo et al. [17] showed a drastic increase in sucrose permeability (as a sign of BBB permeabilization) of the BBB in rats following intravenous administration of P80-PBCA.
Positive_regulation (increase) of Localization (permeabilization) of BBB
2) Confidence 0.03 Published 2010 Journal Part Fibre Toxicol Section Body Doc Link PMC3016300 Disease Relevance 0.25 Pain Relevance 0.13

General Comments

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