INT242445

Context Info Confidence 0.40 First Reported 2008 Last Reported 2010 Negated 1 Speculated 0 Reported most in Body Documents 4 Total Number 4 Disease Relevance 1.31 Pain Relevance 0.41

endosome (Prf1) extracellular region (Prf1) cytoplasmic membrane-bounded vesicle (Prf1) plasma membrane (Prf1) transmembrane transport (Prf1)

Anatomy Link Frequency blood 2 pore 2 Prf1 (Mus musculus)

Pain Link Frequency Relevance Heat Central nervous system 56 98.72 Inflammation 62 86.88 nMDA receptor 10 77.24 long-term potentiation 11 70.32 metalloproteinase 38 69.84 Calcium channel 8 61.68 corticosteroid 98 53.12 fibrosis 9 44.60 dexamethasone 3 43.24 imagery 12 42.80

Disease Link Frequency Relevance Heat Pulmonary Disease 88 99.70 Nicotine Addiction 4 98.44 INFLAMMATION 54 86.88 Apoptosis 28 85.04 Death 10 80.40 Sprains And Strains 7 73.84 Pulmonary Emphysema 5 56.64 Emphysema 7 52.36 Leukemia 11 50.00 Fibrosis 11 44.60

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

These data demonstrated that perforin but not FasL expression was necessary for VP2121–130 peptide induced CNS vascular permeability.

Positive_regulation (necessary) of Gene_expression (expression) of perforin associated with central nervous system

1) Confidence 0.40 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2516328 Disease Relevance 0 Pain Relevance 0.14

Representative flow cytometry analyses (figure 4A) show that the percentages of CD8+ cells expressing perforin upon antigen stimulation increase in BLV-infected sheep cultures (middle panels) but not in the control (left panels).

Positive_regulation (increase) of Gene_expression (expressing) of perforin

2) Confidence 0.09 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736388 Disease Relevance 0 Pain Relevance 0

T lymphocytes from blood and BAL samples from COPD patients have increased levels of GRZ and perforin compared to samples from asymptomatic smokers and nonsmokers (Hodge et al 2006).

Positive_regulation (increased) of Gene_expression (levels) of perforin in blood associated with nicotine addiction and pulmonary disease

3) Confidence 0.03 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2629972 Disease Relevance 1.23 Pain Relevance 0.08

On the other hand, Chameau et al. [105] found by quantitative PCR that corticosterone did not change the mRNA expression of the pore-forming Cav1 subunit of the L-type Ca2+ channel, and ruled out transcriptional mechanisms in the effects they observed.

Neg (not) Positive_regulation (change) of Gene_expression (expression) of pore-forming Cav1 subunit in pore

4) Confidence 0.01 Published 2010 Journal Mol Brain Section Body Doc Link PMC2841592 Disease Relevance 0.07 Pain Relevance 0.19

General Comments

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