INT242445

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Context Info
Confidence 0.40
First Reported 2008
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.31
Pain Relevance 0.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Prf1) extracellular region (Prf1) cytoplasmic membrane-bounded vesicle (Prf1)
plasma membrane (Prf1) transmembrane transport (Prf1)
Anatomy Link Frequency
blood 2
pore 2
Prf1 (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 56 98.72 Very High Very High Very High
Inflammation 62 86.88 High High
nMDA receptor 10 77.24 Quite High
long-term potentiation 11 70.32 Quite High
metalloproteinase 38 69.84 Quite High
Calcium channel 8 61.68 Quite High
corticosteroid 98 53.12 Quite High
fibrosis 9 44.60 Quite Low
dexamethasone 3 43.24 Quite Low
imagery 12 42.80 Quite Low
Disease Link Frequency Relevance Heat
Pulmonary Disease 88 99.70 Very High Very High Very High
Nicotine Addiction 4 98.44 Very High Very High Very High
INFLAMMATION 54 86.88 High High
Apoptosis 28 85.04 High High
Death 10 80.40 Quite High
Sprains And Strains 7 73.84 Quite High
Pulmonary Emphysema 5 56.64 Quite High
Emphysema 7 52.36 Quite High
Leukemia 11 50.00 Quite Low
Fibrosis 11 44.60 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data demonstrated that perforin but not FasL expression was necessary for VP2121–130 peptide induced CNS vascular permeability.


Positive_regulation (necessary) of Gene_expression (expression) of perforin associated with central nervous system
1) Confidence 0.40 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2516328 Disease Relevance 0 Pain Relevance 0.14
Representative flow cytometry analyses (figure 4A) show that the percentages of CD8+ cells expressing perforin upon antigen stimulation increase in BLV-infected sheep cultures (middle panels) but not in the control (left panels).
Positive_regulation (increase) of Gene_expression (expressing) of perforin
2) Confidence 0.09 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736388 Disease Relevance 0 Pain Relevance 0
T lymphocytes from blood and BAL samples from COPD patients have increased levels of GRZ and perforin compared to samples from asymptomatic smokers and nonsmokers (Hodge et al 2006).
Positive_regulation (increased) of Gene_expression (levels) of perforin in blood associated with nicotine addiction and pulmonary disease
3) Confidence 0.03 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2629972 Disease Relevance 1.23 Pain Relevance 0.08
On the other hand, Chameau et al. [105] found by quantitative PCR that corticosterone did not change the mRNA expression of the pore-forming Cav1 subunit of the L-type Ca2+ channel, and ruled out transcriptional mechanisms in the effects they observed.
Neg (not) Positive_regulation (change) of Gene_expression (expression) of pore-forming Cav1 subunit in pore
4) Confidence 0.01 Published 2010 Journal Mol Brain Section Body Doc Link PMC2841592 Disease Relevance 0.07 Pain Relevance 0.19

General Comments

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