INT242455

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Context Info
Confidence 0.62
First Reported 2008
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 3.75
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Ciapin1) nucleus (Ciapin1) cytoplasm (Ciapin1)
Ciapin1 (Mus musculus)
Pain Link Frequency Relevance Heat
Potency 4 71.36 Quite High
palliative 4 32.64 Quite Low
cytokine 4 5.00 Very Low Very Low Very Low
adenocard 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hepatocellular Cancer 312 99.84 Very High Very High Very High
Cancer 228 98.44 Very High Very High Very High
Sprains And Strains 4 93.20 High High
Infection 96 92.68 High High
Hematological Disease 16 88.36 High High
Apoptosis 148 82.88 Quite High
Targeted Disruption 28 80.72 Quite High
Stomach Cancer 4 77.52 Quite High
Cirrhosis 16 54.08 Quite High
Liver Cancer 8 44.04 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Construction of recombinant adenovirus Ad-CIAPIN1 and its effects on CIAPIN1 expression
Regulation (effects) of Gene_expression (expression) of CIAPIN1
1) Confidence 0.62 Published 2008 Journal Carcinogenesis Section Body Doc Link PMC2516489 Disease Relevance 0.85 Pain Relevance 0
Moreover, the prognostic value of altered CIAPIN1 expression and its use as a potential target for cancer therapy are completely unknown and the molecular basis for its effect on cancer biology is unclear.
Regulation (altered) of Gene_expression (expression) of CIAPIN1 associated with cancer
2) Confidence 0.45 Published 2008 Journal Carcinogenesis Section Body Doc Link PMC2516489 Disease Relevance 1.22 Pain Relevance 0
The inhibitory effect of the AdSiCIAPIN1 was shown to be specific because a control AdSiGFP had no effect on CIAPIN1 expression level.
Neg (no) Regulation (effect) of Gene_expression (expression) of CIAPIN1
3) Confidence 0.45 Published 2008 Journal Carcinogenesis Section Body Doc Link PMC2516489 Disease Relevance 0.62 Pain Relevance 0
This blockage of S-phase entry combined with the enhanced cyclinD1 and decreased P27 expression in SMMC-7721 cells conversely substantiated the effect of CIAPIN1 overexpression on HCC, by regulating cyclinD1 and P27 to activate expression of genes necessary for entering into the S phase.
Regulation (effect) of Gene_expression (overexpression) of CIAPIN1 associated with hepatocellular cancer
4) Confidence 0.27 Published 2008 Journal Carcinogenesis Section Body Doc Link PMC2516489 Disease Relevance 1.06 Pain Relevance 0.04

General Comments

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