INT242456

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Context Info
Confidence 0.16
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.29
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Cdk2) cytoplasm (Cdk2) cytosol (Cdk2)
mitosis (Cdk2) nucleus (Cdk2) cytoskeleton (Cdk2)
Cdk2 (Mus musculus)
Pain Link Frequency Relevance Heat
adenocard 2 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
cerebral cortex 1 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
transdermal 1 5.00 Very Low Very Low Very Low
Angina 1 5.00 Very Low Very Low Very Low
Potency 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hepatocellular Cancer 78 91.20 High High
Cancer 77 88.00 High High
Infection 24 81.28 Quite High
Apoptosis 40 71.04 Quite High
Stress 2 54.24 Quite High
Tuberous Sclerosis 11 50.00 Quite Low
Death 11 37.36 Quite Low
Hamartoma 8 27.72 Quite Low
Disease 22 5.00 Very Low Very Low Very Low
Angiomyolipoma 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In order to explore the underlying molecular mechanism of CIAPIN1 affecting the cell cycle progression, we detected the expression of cell cycle-related molecules in AdSiCIAPIN1-infected SMMC-7721 cells, such as cyclinD1, p27, cdk2, cdk4 and p21 by western blot and found cdk2, cdk4 and p21 were not affected (data not show), except CyclyinD1 was downregulated and P27 was upregulated (Figure3F).
cdk2 Binding (cyclinD1) of
1) Confidence 0.16 Published 2008 Journal Carcinogenesis Section Body Doc Link PMC2516489 Disease Relevance 1.01 Pain Relevance 0
However, binding of tuberin to p27 sequesters p27 from Skp2 accompanied by a stabilization of the p27 interaction with cdk2, and hence, Skp2-induced p27 degradation and cell cycle progression is abolished by tuberin’s protective binding to p27.
cdk2 Binding (stabilization) of
2) Confidence 0.06 Published 2008 Journal Current Genomics Section Body Doc Link PMC2691673 Disease Relevance 0.28 Pain Relevance 0

General Comments

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