INT242459

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Context Info
Confidence 0.59
First Reported 2008
Last Reported 2008
Negated 1
Speculated 2
Reported most in Body
Documents 1
Total Number 10
Disease Relevance 10.17
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Ciapin1) nucleus (Ciapin1) cytoplasm (Ciapin1)
Ciapin1 (Mus musculus)
Pain Link Frequency Relevance Heat
Potency 10 63.12 Quite High
palliative 10 5.00 Very Low Very Low Very Low
cytokine 10 5.00 Very Low Very Low Very Low
adenocard 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 70 100.00 Very High Very High Very High
Hepatocellular Cancer 780 99.84 Very High Very High Very High
Cancer 570 99.60 Very High Very High Very High
Apoptosis 370 99.20 Very High Very High Very High
Infection 240 97.48 Very High Very High Very High
Hematological Disease 40 91.08 High High
Targeted Disruption 70 60.72 Quite High
Hepatitis 60 16.68 Low Low
Cirrhosis 40 5.00 Very Low Very Low Very Low
Adenovirus Infection 20 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found that depletion of CIAPIN1 could downregulate Bcl-2 and Bcl-XL and upregulate Bax in AdSiCIAPIN1-transduced tumor cells, suggesting that Bcl-2 family members may contribute partially to the apoptosis of HCC cells with CIAPIN1 depletion.
Negative_regulation (depletion) of CIAPIN1 associated with cancer, hepatocellular cancer and apoptosis
1) Confidence 0.59 Published 2008 Journal Carcinogenesis Section Body Doc Link PMC2516489 Disease Relevance 1.22 Pain Relevance 0
Interestingly, in addition to the inhibition of cell growth, depletion of CIAPIN1 for 96 h triggered apoptosis in all tested HCC cells.
Negative_regulation (depletion) of CIAPIN1 associated with hepatocellular cancer and apoptosis
2) Confidence 0.51 Published 2008 Journal Carcinogenesis Section Body Doc Link PMC2516489 Disease Relevance 1.21 Pain Relevance 0.03
To determine whether the depletion of CIAPIN1 promotes tumor cell death, flow cytometry was performed after infection of adenovirus into four HCC cells.
Spec (whether) Negative_regulation (depletion) of CIAPIN1 associated with cancer, hepatocellular cancer, infection and death
3) Confidence 0.51 Published 2008 Journal Carcinogenesis Section Body Doc Link PMC2516489 Disease Relevance 1.53 Pain Relevance 0
The inhibitory effect of the AdSiCIAPIN1 was shown to be specific because a control AdSiGFP had no effect on CIAPIN1 expression level.
Negative_regulation (effect) of AdSiCIAPIN1
4) Confidence 0.51 Published 2008 Journal Carcinogenesis Section Body Doc Link PMC2516489 Disease Relevance 0.60 Pain Relevance 0
To determine whether the cell cycle distribution has changed after depletion of CIAPIN1 in HCC cells, we performed flow cytometry at 96 h after virus infection.
Spec (whether) Negative_regulation (depletion) of CIAPIN1 associated with hepatocellular cancer and infection
5) Confidence 0.51 Published 2008 Journal Carcinogenesis Section Body Doc Link PMC2516489 Disease Relevance 0.87 Pain Relevance 0
Here, we showed that when overexpressed CIAPIN1 was depleted in HCC, it resulted in multiple antitumor effects in cancer cells such as inhibition of cell growth and induction of apoptosis.
Negative_regulation (depleted) of CIAPIN1 associated with cancer, hepatocellular cancer and apoptosis
6) Confidence 0.43 Published 2008 Journal Carcinogenesis Section Body Doc Link PMC2516489 Disease Relevance 1.28 Pain Relevance 0
Inhibition of cell growth and S-phase entry in HCC cells by depletion of CIAPIN1
Negative_regulation (depletion) of CIAPIN1 associated with hepatocellular cancer
7) Confidence 0.43 Published 2008 Journal Carcinogenesis Section Body Doc Link PMC2516489 Disease Relevance 0.64 Pain Relevance 0
Furthermore, analysis of Bcl-2 family mediators of apoptosis, such as Bcl-2, Bax and Bcl-XL, showed that depletion of CIAPIN1 could downregulate Bcl-2, Bcl-XL and upregulate Bax in AdSiCIAPIN1-transduced cells, suggesting that the apoptotic effect of CIAPIN1 could be partly mediated by the Bcl-2 family (Figure 4D).


Negative_regulation (depletion) of CIAPIN1 associated with apoptosis
8) Confidence 0.43 Published 2008 Journal Carcinogenesis Section Body Doc Link PMC2516489 Disease Relevance 1.64 Pain Relevance 0
As shown in Figure 2B, AdSiCIAPIN1 caused a dramatic reduction in the level of CIAPIN1 mRNA whereas the mock or AdSiGFP could not.
Negative_regulation (reduction) of CIAPIN1 mRNA
9) Confidence 0.43 Published 2008 Journal Carcinogenesis Section Body Doc Link PMC2516489 Disease Relevance 0.49 Pain Relevance 0
However, AdSiCIAPIN1-induced cell death was not completely abolished.
Neg (not) Negative_regulation (abolished) of AdSiCIAPIN1-induced associated with death
10) Confidence 0.37 Published 2008 Journal Carcinogenesis Section Body Doc Link PMC2516489 Disease Relevance 0.69 Pain Relevance 0

General Comments

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