INT242460

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Context Info
Confidence 0.59
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 4.97
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Ciapin1) nucleus (Ciapin1) cytoplasm (Ciapin1)
Ciapin1 (Mus musculus)
Pain Link Frequency Relevance Heat
Potency 5 96.88 Very High Very High Very High
palliative 5 5.00 Very Low Very Low Very Low
cytokine 5 5.00 Very Low Very Low Very Low
adenocard 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hepatocellular Cancer 390 99.84 Very High Very High Very High
Infection 120 98.52 Very High Very High Very High
Cancer 285 97.84 Very High Very High Very High
Apoptosis 185 96.64 Very High Very High Very High
Hematological Disease 20 91.64 High High
Targeted Disruption 35 89.52 High High
Death 35 70.28 Quite High
Recurrence 10 27.04 Quite Low
Cirrhosis 20 24.20 Low Low
Hepatitis 30 23.80 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As shown in Figure 2A, the suppression of CIAPIN1 expression was detected as early as 48 h after infection, and the suppression was up to 80% in the cells infected with AdSiCIAPIN1 at 96 h.
Negative_regulation (suppression) of Gene_expression (expression) of CIAPIN1 associated with infection
1) Confidence 0.59 Published 2008 Journal Carcinogenesis Section Body Doc Link PMC2516489 Disease Relevance 0.71 Pain Relevance 0
In conclusion, our results show that the significant downregulation of CIAPIN1 expression in HCC cells inhibits cell growth in vitro and in vivo and induces the cancer cell apoptosis.
Negative_regulation (downregulation) of Gene_expression (expression) of CIAPIN1 associated with cancer, hepatocellular cancer and apoptosis
2) Confidence 0.59 Published 2008 Journal Carcinogenesis Section Body Doc Link PMC2516489 Disease Relevance 1.35 Pain Relevance 0
Our results show that AdSiRNA can downregulate CIAPIN1 expression effectively by up to 80% in HCC cells with great specificity, indicating the potency of adenovirus-based RNAi as an effective strategy for cancer therapy.
Negative_regulation (downregulate) of Gene_expression (expression) of CIAPIN1 associated with cancer, hepatocellular cancer and potency
3) Confidence 0.51 Published 2008 Journal Carcinogenesis Section Body Doc Link PMC2516489 Disease Relevance 0.96 Pain Relevance 0.05
Here, we showed that when overexpressed CIAPIN1 was depleted in HCC, it resulted in multiple antitumor effects in cancer cells such as inhibition of cell growth and induction of apoptosis.
Negative_regulation (depleted) of Gene_expression (overexpressed) of CIAPIN1 associated with cancer, hepatocellular cancer and apoptosis
4) Confidence 0.43 Published 2008 Journal Carcinogenesis Section Body Doc Link PMC2516489 Disease Relevance 1.28 Pain Relevance 0
Altogether, these data indicated that the AdSiRNA could suppress effectively the CIAPIN1 overexpression in HCC cells.


Negative_regulation (suppress) of Gene_expression (overexpression) of CIAPIN1 associated with hepatocellular cancer
5) Confidence 0.43 Published 2008 Journal Carcinogenesis Section Body Doc Link PMC2516489 Disease Relevance 0.68 Pain Relevance 0

General Comments

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