INT242464

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Context Info
Confidence 0.61
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 3.32
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Ciapin1) nucleus (Ciapin1) cytoplasm (Ciapin1)
Ciapin1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 3 99.98 Very High Very High Very High
Potency 3 11.48 Low Low
palliative 3 5.00 Very Low Very Low Very Low
adenocard 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 111 99.98 Very High Very High Very High
Hematological Disease 12 96.16 Very High Very High Very High
Cancer 171 94.84 High High
Hepatocellular Cancer 234 93.84 High High
Infection 72 79.48 Quite High
Death 21 79.36 Quite High
Targeted Disruption 21 64.00 Quite High
Hepatitis 18 5.00 Very Low Very Low Very Low
Cirrhosis 12 5.00 Very Low Very Low Very Low
Adenovirus Infection 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cytokine-induced antiapoptotic molecule (CIAPIN1), a recently reported antiapoptotic molecule which plays an essential role in mouse definitive hematopoiesis, is considered a downstream effecter of the receptor tyrosine kinaseĀ–Ras signaling pathway.
Positive_regulation (induced) of CIAPIN1 associated with hematological disease and cytokine
1) Confidence 0.61 Published 2008 Journal Carcinogenesis Section Abstract Doc Link PMC2516489 Disease Relevance 0.84 Pain Relevance 0.05
Furthermore, analysis of Bcl-2 family mediators of apoptosis, such as Bcl-2, Bax and Bcl-XL, showed that depletion of CIAPIN1 could downregulate Bcl-2, Bcl-XL and upregulate Bax in AdSiCIAPIN1-transduced cells, suggesting that the apoptotic effect of CIAPIN1 could be partly mediated by the Bcl-2 family (Figure 4D).


Positive_regulation (effect) of CIAPIN1 associated with apoptosis
2) Confidence 0.50 Published 2008 Journal Carcinogenesis Section Body Doc Link PMC2516489 Disease Relevance 1.57 Pain Relevance 0
The expression of p53 protein was greatly enhanced in AdSiCIAPIN1-infected HepG2 and SMMC-7721 cells (supplementary Figure A is available at Carcinogenesis Online).
Positive_regulation (enhanced) of AdSiCIAPIN1
3) Confidence 0.44 Published 2008 Journal Carcinogenesis Section Body Doc Link PMC2516489 Disease Relevance 0.91 Pain Relevance 0

General Comments

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