INT242467

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Context Info
Confidence 0.70
First Reported 2008
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 24
Disease Relevance 27.67
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Ciapin1) nucleus (Ciapin1) cytoplasm (Ciapin1)
Anatomy Link Frequency
Chang liver 6
liver 2
Ciapin1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 24 86.44 High High
Potency 24 85.28 High High
palliative 24 50.24 Quite High
adenocard 24 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hepatocellular Cancer 1872 100.00 Very High Very High Very High
Apoptosis 888 100.00 Very High Very High Very High
Cancer 1368 99.36 Very High Very High Very High
Infection 576 98.72 Very High Very High Very High
Targeted Disruption 168 98.72 Very High Very High Very High
Stomach Cancer 24 95.12 Very High Very High Very High
Hematological Disease 96 94.64 High High
Cirrhosis 96 91.12 High High
Death 168 90.52 High High
Cleidocranial Dysplasia 24 86.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Tumorigenesis is associated with multiple factors and CIAPIN1 overexpression may be an important factor in HCC; thus, we hypothesize that knock down of CIAPIN1 expression may inhibit the growth of HCC in which CIAPIN1 is overexpressed.
Positive_regulation (overexpression) of Gene_expression (overexpression) of CIAPIN1 associated with targeted disruption and hepatocellular cancer
1) Confidence 0.70 Published 2008 Journal Carcinogenesis Section Body Doc Link PMC2516489 Disease Relevance 1.28 Pain Relevance 0
These results suggest that CIAPIN1 overexpression may be essential for maintaining cell proliferation as well as cell survival in HCC.
Positive_regulation (overexpression) of Gene_expression (overexpression) of CIAPIN1 associated with hepatocellular cancer
2) Confidence 0.70 Published 2008 Journal Carcinogenesis Section Body Doc Link PMC2516489 Disease Relevance 1.28 Pain Relevance 0
Our studies here were designed to test whether the more advantageous AdSiRNA can be applied to target HCC cells selectively with overexpression of a recently reported antiapoptosis gene, CIAPIN1, which is overexpressed in a higher percentage of HCC patients.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of CIAPIN1 associated with hepatocellular cancer
3) Confidence 0.70 Published 2008 Journal Carcinogenesis Section Body Doc Link PMC2516489 Disease Relevance 1.03 Pain Relevance 0.04
In this study, we detected that CIAPIN1 expression is elevated in majority HCC patient samples and HCC cell lines, and consequently, we hypothesized that overexpression of CIAPIN1 may be associated with hepatocarcinogenesis and knock down of CIAPIN1 may inhibit tumorigenic growth of HCC in which CIAPIN1 is overexpressed.
Positive_regulation (overexpression) of Gene_expression (overexpression) of CIAPIN1 associated with targeted disruption and hepatocellular cancer
4) Confidence 0.70 Published 2008 Journal Carcinogenesis Section Body Doc Link PMC2516489 Disease Relevance 1.01 Pain Relevance 0
In this study, we detected that CIAPIN1 expression is elevated in majority HCC patient samples and HCC cell lines, and consequently, we hypothesized that overexpression of CIAPIN1 may be associated with hepatocarcinogenesis and knock down of CIAPIN1 may inhibit tumorigenic growth of HCC in which CIAPIN1 is overexpressed.
Positive_regulation (elevated) of Gene_expression (expression) of CIAPIN1 associated with targeted disruption and hepatocellular cancer
5) Confidence 0.70 Published 2008 Journal Carcinogenesis Section Body Doc Link PMC2516489 Disease Relevance 1.31 Pain Relevance 0
Therefore, our studies suggest that knock down of CIAPIN1 by adenovirus-delivered siRNA may be a potential therapeutic strategy in the treatment of HCC in which CIAPIN1 is overexpressed.


Positive_regulation (overexpressed) of Gene_expression (overexpressed) of CIAPIN1 associated with targeted disruption and hepatocellular cancer
6) Confidence 0.70 Published 2008 Journal Carcinogenesis Section Body Doc Link PMC2516489 Disease Relevance 1.13 Pain Relevance 0
In addition to showing the successful use of AdSiRNA in silencing CIAPIN1 overexpressed in HCC cells, our results also indicate that CIAPIN1 might serve as a novel promising therapeutic target for HCCs.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of CIAPIN1 associated with hepatocellular cancer
7) Confidence 0.70 Published 2008 Journal Carcinogenesis Section Body Doc Link PMC2516489 Disease Relevance 0.75 Pain Relevance 0
Our studies here were designed to test whether the more advantageous AdSiRNA can be applied to target HCC cells selectively with overexpression of a recently reported antiapoptosis gene, CIAPIN1, which is overexpressed in a higher percentage of HCC patients.
Positive_regulation (overexpression) of Gene_expression (overexpression) of CIAPIN1 associated with hepatocellular cancer
8) Confidence 0.70 Published 2008 Journal Carcinogenesis Section Body Doc Link PMC2516489 Disease Relevance 1.04 Pain Relevance 0.04
In this study, we detected that CIAPIN1 expression is elevated in majority HCC patient samples and HCC cell lines, and consequently, we hypothesized that overexpression of CIAPIN1 may be associated with hepatocarcinogenesis and knock down of CIAPIN1 may inhibit tumorigenic growth of HCC in which CIAPIN1 is overexpressed.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of CIAPIN1 associated with targeted disruption and hepatocellular cancer
9) Confidence 0.70 Published 2008 Journal Carcinogenesis Section Body Doc Link PMC2516489 Disease Relevance 0.97 Pain Relevance 0
Here, we showed that when overexpressed CIAPIN1 was depleted in HCC, it resulted in multiple antitumor effects in cancer cells such as inhibition of cell growth and induction of apoptosis.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of CIAPIN1 associated with cancer, hepatocellular cancer and apoptosis
10) Confidence 0.70 Published 2008 Journal Carcinogenesis Section Body Doc Link PMC2516489 Disease Relevance 1.27 Pain Relevance 0
This blockage of S-phase entry combined with the enhanced cyclinD1 and decreased P27 expression in SMMC-7721 cells conversely substantiated the effect of CIAPIN1 overexpression on HCC, by regulating cyclinD1 and P27 to activate expression of genes necessary for entering into the S phase.
Positive_regulation (overexpression) of Gene_expression (overexpression) of CIAPIN1 associated with hepatocellular cancer
11) Confidence 0.70 Published 2008 Journal Carcinogenesis Section Body Doc Link PMC2516489 Disease Relevance 1.05 Pain Relevance 0.04
Our data indicate that compared with the Chang liver cells, the expression of CIAPIN1 was significantly increased in all four HCC cell lines (Figure 1C).


Positive_regulation (increased) of Gene_expression (expression) of CIAPIN1 in Chang liver associated with hepatocellular cancer
12) Confidence 0.70 Published 2008 Journal Carcinogenesis Section Body Doc Link PMC2516489 Disease Relevance 0.97 Pain Relevance 0
It was clear that the tumor tissue specimens had a drastic increase of CIAPIN1 expression as compared with the normal liver tissue, which was consistent with the level of CIAPIN1 protein expression determined by immunohistochemical staining.
Positive_regulation (increase) of Gene_expression (expression) of CIAPIN1 in liver associated with cancer
13) Confidence 0.70 Published 2008 Journal Carcinogenesis Section Body Doc Link PMC2516489 Disease Relevance 1.38 Pain Relevance 0
Tumorigenesis is associated with multiple factors and CIAPIN1 overexpression may be an important factor in HCC; thus, we hypothesize that knock down of CIAPIN1 expression may inhibit the growth of HCC in which CIAPIN1 is overexpressed.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of CIAPIN1 associated with targeted disruption and hepatocellular cancer
14) Confidence 0.70 Published 2008 Journal Carcinogenesis Section Body Doc Link PMC2516489 Disease Relevance 1.11 Pain Relevance 0
Chang liver was used as references for CIAPIN1 expression.
Positive_regulation (references) of Gene_expression (expression) of CIAPIN1 in Chang liver
15) Confidence 0.50 Published 2008 Journal Carcinogenesis Section Body Doc Link PMC2516489 Disease Relevance 1.02 Pain Relevance 0
Furthermore, CIAPIN1 was found to act as an antiapoptotic molecule in vivo because CIAPIN1?
Positive_regulation (because) of Gene_expression (found) of CIAPIN1
16) Confidence 0.50 Published 2008 Journal Carcinogenesis Section Body Doc Link PMC2516489 Disease Relevance 1.06 Pain Relevance 0.05
Altogether, these data indicated that the AdSiRNA could suppress effectively the CIAPIN1 overexpression in HCC cells.


Positive_regulation (overexpression) of Gene_expression (overexpression) of CIAPIN1 associated with hepatocellular cancer
17) Confidence 0.50 Published 2008 Journal Carcinogenesis Section Body Doc Link PMC2516489 Disease Relevance 0.67 Pain Relevance 0
Induction of apoptosis in HCC cells by adenovirus-delivered CIAPIN1 siRNA
Positive_regulation (Induction) of Gene_expression (delivered) of CIAPIN1 siRNA associated with hepatocellular cancer and apoptosis
18) Confidence 0.50 Published 2008 Journal Carcinogenesis Section Body Doc Link PMC2516489 Disease Relevance 1.41 Pain Relevance 0
To test if apoptosis can be triggered in normal cells that do not overexpress CIAPIN1, we also infected normal Chang liver with AdSiRNA.
Neg (not) Positive_regulation (overexpress) of Neg (not) Gene_expression (overexpress) of CIAPIN1 in Chang liver associated with apoptosis
19) Confidence 0.50 Published 2008 Journal Carcinogenesis Section Body Doc Link PMC2516489 Disease Relevance 1.90 Pain Relevance 0
Induction of apoptosis in HCC cells by adenovirus-delivered CIAPIN1 siRNA
Positive_regulation (delivered) of Gene_expression (delivered) of CIAPIN1 siRNA associated with hepatocellular cancer and apoptosis
20) Confidence 0.50 Published 2008 Journal Carcinogenesis Section Body Doc Link PMC2516489 Disease Relevance 1.35 Pain Relevance 0

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