INT242469

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Context Info
Confidence 0.06
First Reported 2008
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.49
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Tpt1) extracellular space (Tpt1) transcription factor binding (Tpt1)
cytoplasm (Tpt1)
Anatomy Link Frequency
intestine 1
Tpt1 (Mus musculus)
Pain Link Frequency Relevance Heat
Crohn's disease 1 72.92 Quite High
cytokine 2 5.00 Very Low Very Low Very Low
spastic colon 1 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
adenocard 1 5.00 Very Low Very Low Very Low
Potency 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hepatocellular Cancer 78 88.20 High High
Cancer 59 87.20 High High
Obesity 2 80.44 Quite High
Infection 25 78.28 Quite High
Apoptosis 38 77.20 Quite High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

1 73.24 Quite High
Disease 4 72.92 Quite High
Gastrointestinal Disease 3 72.16 Quite High
Death 9 43.52 Quite Low
Targeted Disruption 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CCNA1 belongs to the cyclin family, and binds to important cell cycle regulators such as E2F, Rb, CDK2 and p21, but its abundance in the intestine is low [34].
Regulation (regulators) of p21 in intestine
1) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944884 Disease Relevance 0.39 Pain Relevance 0.04
In order to explore the underlying molecular mechanism of CIAPIN1 affecting the cell cycle progression, we detected the expression of cell cycle-related molecules in AdSiCIAPIN1-infected SMMC-7721 cells, such as cyclinD1, p27, cdk2, cdk4 and p21 by western blot and found cdk2, cdk4 and p21 were not affected (data not show), except CyclyinD1 was downregulated and P27 was upregulated (Figure3F).
Neg (not) Regulation (affected) of p21
2) Confidence 0.06 Published 2008 Journal Carcinogenesis Section Body Doc Link PMC2516489 Disease Relevance 1.02 Pain Relevance 0

General Comments

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